Literature DB >> 23964169

Synthesis and anti-histaminic activity of some novel pyrimidines.

Sk A Rahaman1, Y Rajendra Pasad, Phani Kumar, Bharath Kumar.   

Abstract

Novel pyrimidines were prepared by the condensation of chalcones of 4'-piperazine acetophenone with guanidine HCl. The structures of the synthesized compounds RP 1-5 were assigned on the basis of elemental analysis, IR, (1)H NMR and mass spectroscopy. These compounds were also screened for anti-histaminic activity. The recorded percentage of histamine inhibition showed a significant anti-histaminic activity when compared to the reference anti-histaminic drug mepiramine.

Entities:  

Keywords:  Anti-histaminic activity; Chalcone; Pyrimidine

Year:  2009        PMID： 23964169      PMCID： PMC3731017          DOI： 10.1016/j.jsps.2009.08.001

Source DB:  PubMed          Journal:  Saudi Pharm J        ISSN： 1319-0164            Impact factor:   4.330


  3 in total

1.  Comparative studies on the antirhinovirus activity and the mode of action of the rhinovirus capsid binding agents, chalcone amides.

Authors:  Y Ninomiya; N Shimma; H Ishitsuka
Journal:  Antiviral Res       Date:  1990-02       Impact factor: 5.970

2.  Direct and specific inactivation of rhinovirus by chalcone Ro 09-0410.

Authors:  H Ishitsuka; Y T Ninomiya; C Ohsawa; M Fujiu; Y Suhara
Journal:  Antimicrob Agents Chemother       Date:  1982-10       Impact factor: 5.191

3.  Retinobenzoic acids. 5. Retinoidal activities of compounds having a trimethylsilyl or trimethylgermyl group(s) in human promyelocytic leukemia cells HL-60.

Authors:  T Yamakawa; H Kagechika; E Kawachi; Y Hashimoto; K Shudo
Journal:  J Med Chem       Date:  1990-05       Impact factor: 7.446
  3 in total
  4 in total

Review 1.  Research developments in the syntheses, anti-inflammatory activities and structure-activity relationships of pyrimidines.

Authors:  Haroon Ur Rashid; Marco Antonio Utrera Martines; Adriana Pereira Duarte; Juliana Jorge; Shagufta Rasool; Riaz Muhammad; Nasir Ahmad; Muhammad Naveed Umar
Journal:  RSC Adv       Date:  2021-02-03       Impact factor: 3.361

2.  Structural and theoretical studies of 4-chloro-2-methyl-6-oxo-3,6-dideuteropyrimidin-1-ium chloride (d 6).

Authors:  Ray J Butcher; Andrew P Purdy; Sean A Fischer; Daniel Gunlycke
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2021-03-19

Review 3.  Significance and biological importance of pyrimidine in the microbial world.

Authors:  Vinita Sharma; Nitin Chitranshi; Ajay Kumar Agarwal
Journal:  Int J Med Chem       Date:  2014-03-23

4.  Synthesis, characterization and in silico biological activity of some 2-(N,N-dimethyl guanidinyl)-4,6-diaryl pyrimidines.

Authors:  Rajasekhar Komarla Kumarachari; Sivakumar Peta; Abdrrahman Shemsu Surur; Yenus Tadesse Mekonnen
Journal:  J Pharm Bioallied Sci       Date:  2016 Jul-Sep
  4 in total

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