Literature DB >> 23962988

Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1.

Xiubo Du1, Hongyan Li, Xinghao Wang, Qiong Liu, Jiazuan Ni, Hongzhe Sun.   

Abstract

The N-terminus of hCTR1 was demonstrated to bind three Cu(+) ions tightly (log K = 14.92) and reversibly via its Met-rich motifs. Ag(+) binds to the protein with the same stoichiometry but much lower affinities than Cu(+). The protein also coordinates two Cu(2+) ions through its ATCUN motif and His-rich motif with lower affinity. This study provides an insight into the selectivity of the transporter.

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Year:  2013        PMID： 23962988     DOI： 10.1039/c3cc45360j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  13 in total

1.  Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.

Authors:  Brandon L Logeman; L Kent Wood; Jaekwon Lee; Dennis J Thiele
Journal:  J Biol Chem       Date:  2017-05-15       Impact factor: 5.157

2.  Dynamical interplay between the human high-affinity copper transporter hCtr1 and its cognate metal ion.

Authors:  Gulshan Walke; Jana Aupič; Hadeel Kashoua; Pavel Janoš; Shelly Meron; Yulia Shenberger; Zena Qasem; Lada Gevorkyan-Airapetov; Alessandra Magistrato; Sharon Ruthstein
Journal:  Biophys J       Date:  2022-02-22       Impact factor: 3.699

3.  Improved bioactivity of antimicrobial peptides by addition of amino-terminal copper and nickel (ATCUN) binding motifs.

Authors:  M Daben Libardo; Jorge L Cervantes; Juan C Salazar; Alfredo M Angeles-Boza
Journal:  ChemMedChem       Date:  2014-05-06       Impact factor: 3.466

4.  Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain.

Authors:  Helena Öhrvik; Brandon Logeman; Boris Turk; Thomas Reinheckel; Dennis J Thiele
Journal:  J Biol Chem       Date:  2016-05-03       Impact factor: 5.157

5.  Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.

Authors:  Helena Öhrvik; Yasuhiro Nose; L Kent Wood; Byung-Eun Kim; Sophie-Charlotte Gleber; Martina Ralle; Dennis J Thiele
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-28       Impact factor: 11.205

6.  How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1.

Authors:  Helena Ohrvik; Dennis J Thiele
Journal:  Ann N Y Acad Sci       Date:  2014-02-20       Impact factor: 5.691

Review 7.  The role of Ctr1 and Ctr2 in mammalian copper homeostasis and platinum-based chemotherapy.

Authors:  Helena Öhrvik; Dennis J Thiele
Journal:  J Trace Elem Med Biol       Date:  2014-03-24       Impact factor: 3.849

8.  SilE is an intrinsically disordered periplasmic "molecular sponge" involved in bacterial silver resistance.

Authors:  Karishma R Asiani; Huw Williams; Louise Bird; Matthew Jenner; Mark S Searle; Jon L Hobman; David J Scott; Panos Soultanas
Journal:  Mol Microbiol       Date:  2016-05-07       Impact factor: 3.501

9.  The Extracellular Domain of Human High Affinity Copper Transporter (hNdCTR1), Synthesized by E. coli Cells, Chelates Silver and Copper Ions In Vivo.

Authors:  Tatiana P Sankova; Iurii A Orlov; Andrey N Saveliev; Demid A Kirilenko; Polina S Babich; Pavel N Brunkov; Ludmila V Puchkova
Journal:  Biomolecules       Date:  2017-11-03

Review 10.  Advances in the Study of Structural Modification and Biological Activities of Anoplin.

Authors:  Ye Wu; Rui Huang; Jin-Mei Jin; Li-Jun Zhang; Hong Zhang; Hong-Zhuan Chen; Li-Li Chen; Xin Luan
Journal:  Front Chem       Date:  2020-07-07       Impact factor: 5.221
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