Literature DB >> 23961760

The preparation of trisubstituted alkenyl nucleoside phosphonates under ultrasound-assisted olefin cross-metathesis.

Ozkan Sari1, Manabu Hamada, Vincent Roy, Steven P Nolan, Luigi A Agrofoglio.   

Abstract

Intermolecular ultrasound-assisted olefin cross-metathesis is reported. This approach allows an easy access to challenging trisubstituted alkenyl nucleoside phosphonates. Regioselective chemoenzymatic deacetylation and Mitsunobu coupling are also described.

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Year:  2013        PMID： 23961760     DOI： 10.1021/ol401922r

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.

Authors:  Elisa Pileggi; Michaela Serpi; Graciela Andrei; Dominique Schols; Robert Snoeck; Fabrizio Pertusati
Journal:  Bioorg Med Chem       Date:  2018-05-23       Impact factor: 3.641

2.  Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.

Authors:  Maxime Bessières; Vincent Hervin; Vincent Roy; Agnès Chartier; Robert Snoeck; Graciela Andrei; Jean-François Lohier; Luigi A Agrofoglio
Journal:  Eur J Med Chem       Date:  2018-01-31       Impact factor: 6.514
  2 in total

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