Essam Taher M A Gaballah1. 1. Professor of Oral Pathology, Mansoura Faculty of Dentistry, Egypt.
Abstract
UNLABELLED: Salivary gland neoplasms comprise phenotypically and biologically diverse lesions of uncertain histogenesis. OBJECTIVES: The present study was carried out to assess the immunohistochemical expression of HER-2/neu protein and of silver binding nucleolar organizer regions in normal salivary tissue. MATERIALS AND METHODS: Twenty paraffin blocks of salivary tumors containing surrounding normal salivary tissue were used in the study. One section was processed to investigate HER-2/neu protein expression and another section was stained to assess the mean Ag NOR counts in normal salivary tissue. RESULTS: Only two cases of the studied normal salivary tissue showed HER-2/neu expression (10%), which was expressed only in ductal cells with 4.2 ± 2.1 mean number of reactive cells per five high power fields (HPFs). Statistically significant (P = 0.01) higher mean Ag NOR counts in ductal (2 ± 0.83) than in acinar cells (1.2 ± 0.01) of normal salivary tissue were found. CONCLUSION: It was concluded from the data of the present study that ductal cells of normal salivary tissue are a proliferative pool and an oncogenic target which plays an important role in the histogenesis of salivary gland tumors.
UNLABELLED: Salivary gland neoplasms comprise phenotypically and biologically diverse lesions of uncertain histogenesis. OBJECTIVES: The present study was carried out to assess the immunohistochemical expression of HER-2/neu protein and of silver binding nucleolar organizer regions in normal salivary tissue. MATERIALS AND METHODS: Twenty paraffin blocks of salivary tumors containing surrounding normal salivary tissue were used in the study. One section was processed to investigate HER-2/neu protein expression and another section was stained to assess the mean Ag NOR counts in normal salivary tissue. RESULTS: Only two cases of the studied normal salivary tissue showed HER-2/neu expression (10%), which was expressed only in ductal cells with 4.2 ± 2.1 mean number of reactive cells per five high power fields (HPFs). Statistically significant (P = 0.01) higher mean Ag NOR counts in ductal (2 ± 0.83) than in acinar cells (1.2 ± 0.01) of normal salivary tissue were found. CONCLUSION: It was concluded from the data of the present study that ductal cells of normal salivary tissue are a proliferative pool and an oncogenic target which plays an important role in the histogenesis of salivary gland tumors.
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