Literature DB >> 23959989

Cardiac stem cell niche, MMP9, and culture and differentiation of embryonic stem cells.

Paras Kumar Mishra1, Nicholas John Kuypers, Shree Ram Singh, Noel Diaz Leiberh, Vishalakshi Chavali, Suresh C Tyagi.   

Abstract

Embryonic stem cells (ESC) are totipotent, self-renewing, and clonogenic, having potential to differentiate into a wide variety of cell types. Due to regenerative capability, it has tremendous potential for treating myocardial infarction (death of myocardial tissue) and type 1 diabetes (death of pancreatic beta cells). Understanding the components regulating ESC differentiation is the key to unlock the regenerative potential of ESC-based therapies. Both the stiffness of extracellular matrix (ECM) and surrounding niche/microenvironment play pivotal roles in ESC differentiation. Matrix metalloproteinase-9 (MMP9) induces fibrosis that causes stiffness of the ECM and impairs differentiation of cardiac stem cells into cardiomyocytes. Here, we describe the method of ESC culture and differentiation, and the expression of MMP9 and its inhibitor, tissue inhibitor of metalloproteinase-4 (TIMP4) in differentiating ESC.

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Year:  2013        PMID： 23959989      PMCID： PMC4697739          DOI： 10.1007/978-1-62703-508-8_13

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  35 in total

1.  Recent concepts for the roles of progenitor/stem cell niche in heart repair.

Authors:  Yuliang Feng; Xi-Yong Yu; Yigang Wang
Journal:  Am J Cardiovasc Dis       Date:  2011-12-15

Review 2.  Gene regulatory networks in the evolution and development of the heart.

Authors:  Eric N Olson
Journal:  Science       Date:  2006-09-29       Impact factor: 47.728

3.  Migration and proliferation of human mesenchymal stem cells is stimulated by different regions of the mechano-growth factor prohormone.

Authors:  John M Collins; Paul H Goldspink; Brenda Russell
Journal:  J Mol Cell Cardiol       Date:  2010-09-27       Impact factor: 5.000

Review 4.  Stem cells for cardiac repair in acute myocardial infarction.

Authors:  Jan Otto Beitnes; Ketil Lunde; Jan E Brinchmann; Svend Aakhus
Journal:  Expert Rev Cardiovasc Ther       Date:  2011-08

5.  Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells.

Authors:  Jeff Holst; Sarah Watson; Megan S Lord; Steven S Eamegdool; Daniel V Bax; Lisa B Nivison-Smith; Alexey Kondyurin; Liang Ma; Andres F Oberhauser; Anthony S Weiss; John E J Rasko
Journal:  Nat Biotechnol       Date:  2010-10-03       Impact factor: 54.908

6.  Ablation of MMP9 induces survival and differentiation of cardiac stem cells into cardiomyocytes in the heart of diabetics: a role of extracellular matrix.

Authors:  Paras Kumar Mishra; Vishalakshi Chavali; Naira Metreveli; Suresh C Tyagi
Journal:  Can J Physiol Pharmacol       Date:  2012-03-06       Impact factor: 2.273

7.  Molecular mapping of the regenerative niche in a murine model of myocardial infarction.

Authors:  Gabriela Dornelles Alves; Mariana Pazzine; Luisa Maria Gomes de Macedo Braga; Maria Cláudia Irigoyen; Kátia De Angelis; Nilo Ikuta; Melissa Camassola; Nance Beyer Nardi
Journal:  Int J Mol Med       Date:  2011-11-29       Impact factor: 4.101

8.  Recapitulation of the embryonic cardiovascular progenitor cell niche.

Authors:  Katja Schenke-Layland; Ali Nsair; Ben Van Handel; Ekaterini Angelis; Jessica M Gluck; Miriam Votteler; Joshua I Goldhaber; Hanna K Mikkola; Michael Kahn; William R Maclellan
Journal:  Biomaterials       Date:  2011-01-22       Impact factor: 12.479

Review 9.  Stem cell treatment for acute myocardial infarction.

Authors:  David M Clifford; Sheila A Fisher; Susan J Brunskill; Carolyn Doree; Anthony Mathur; Suzanne Watt; Enca Martin-Rendon
Journal:  Cochrane Database Syst Rev       Date:  2012-02-15

10.  Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating.

Authors:  Adam J Engler; Christine Carag-Krieger; Colin P Johnson; Matthew Raab; Hsin-Yao Tang; David W Speicher; Joseph W Sanger; Jean M Sanger; Dennis E Discher
Journal:  J Cell Sci       Date:  2008-10-28       Impact factor: 5.285
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  6 in total

1.  Generating double knockout mice to model genetic intervention for diabetic cardiomyopathy in humans.

Authors:  Vishalakshi Chavali; Shyam Sundar Nandi; Shree Ram Singh; Paras Kumar Mishra
Journal:  Methods Mol Biol       Date:  2014

Review 2.  Epigenetic mechanisms underlying cardiac degeneration and regeneration.

Authors:  Pankaj Chaturvedi; Suresh C Tyagi
Journal:  Int J Cardiol       Date:  2014-02-20       Impact factor: 4.164

3.  Study of Bone Marrow and Embryonic Stem Cell-Derived Human Mesenchymal Stem Cells for Treatment of Escherichia coli Endotoxin-Induced Acute Lung Injury in Mice.

Authors:  Qi Hao; Ying-Gang Zhu; Antoine Monsel; Stephane Gennai; Travis Lee; Fengyun Xu; Jae-Woo Lee
Journal:  Stem Cells Transl Med       Date:  2015-05-21       Impact factor: 6.940

4.  Intracellular matrix metalloproteinase-9 mediates epigenetic modifications and autophagy to regulate differentiation in human cardiac stem cells.

Authors:  Santosh K Yadav; Paras K Mishra
Journal:  Stem Cells       Date:  2021-01-12       Impact factor: 5.845

Review 5.  Reprogramming for cardiac regeneration.

Authors:  Christophe Michel Raynaud; Faizzan Syed Ahmad; Mona Allouba; Haissam Abou-Saleh; Kathy O Lui; Magdi Yacoub
Journal:  Glob Cardiol Sci Pract       Date:  2014-10-16

6.  MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro.

Authors:  Santosh K Yadav; Tyler N Kambis; Sumit Kar; Song Y Park; Paras K Mishra
Journal:  Cell Death Dis       Date:  2020-03-13       Impact factor: 8.469
  6 in total

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