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Literature DB >> 23959692

Making scent of the presence and local translation of odorant receptor mRNAs in olfactory axons.

Caroline Dubacq¹, Coralie Fouquet, Alain Trembleau.

Abstract

Rodents contain in their genome more than 1000 functional odorant receptor genes, which are specifically expressed by the olfactory sensory neurons projecting from the olfactory epithelium to the olfactory bulb. Strong evidence for the presence and local translation of odorant receptor mRNAs in the axon of olfactory sensory neurons was obtained, but no function has been assigned to these axonal mRNAs yet. The aim of this review is to discuss the evidence for the presence and local translation of odorant receptor mRNAs in olfactory sensory axons, and to speculate on their possible function in the wiring of the mouse olfactory sensory projections.

Entities: Chemical Disease Gene Species

Keywords: axon guidance; local translation; mouse; odorant receptor; olfactory system

Mesh：

Substances：
RNA, Messenger

Year: 2013 PMID： 23959692 PMCID： PMC4879812 DOI： 10.1002/dneu.22122

Source DB: PubMed Journal: Dev Neurobiol ISSN： 1932-8451 Impact factor: 3.964

50 in total

1. Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation.

Authors: D S Campbell; C E Holt
Journal: Neuron Date: 2001-12-20 Impact factor: 17.173

2. Migration of proteins along the axons of the sciatic nerve.

Authors: B DROZ; C P LEBLOND
Journal: Science Date: 1962-09-28 Impact factor: 47.728

3. Odorant responsiveness of embryonic mouse olfactory sensory neurons expressing the odorant receptors S1 or MOR23.

Authors: Rebecca S Lam; Peter Mombaerts
Journal: Eur J Neurosci Date: 2013-05-20 Impact factor: 3.386

Review 4. Axonal wiring in the mouse olfactory system.

Authors: Peter Mombaerts
Journal: Annu Rev Cell Dev Biol Date: 2006 Impact factor: 13.827

5. A neuronal identity code for the odorant receptor-specific and activity-dependent axon sorting.

Authors: Shou Serizawa; Kazunari Miyamichi; Haruki Takeuchi; Yuya Yamagishi; Misao Suzuki; Hitoshi Sakano
Journal: Cell Date: 2006-12-01 Impact factor: 41.582

6. Mapping of class I and class II odorant receptors to glomerular domains by two distinct types of olfactory sensory neurons in the mouse.

Authors: Thomas Bozza; Anne Vassalli; Stefan Fuss; Jing-Ji Zhang; Brian Weiland; Rodrigo Pacifico; Paul Feinstein; Peter Mombaerts
Journal: Neuron Date: 2009-01-29 Impact factor: 17.173

7. Evidence for developmentally regulated local translation of odorant receptor mRNAs in the axons of olfactory sensory neurons.

Authors: Caroline Dubacq; Sophie Jamet; Alain Trembleau
Journal: J Neurosci Date: 2009-08-19 Impact factor: 6.167

Making scent of the presence and local translation of odorant receptor mRNAs in olfactory axons.

1. Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation.

2. Migration of proteins along the axons of the sciatic nerve.

3. Odorant responsiveness of embryonic mouse olfactory sensory neurons expressing the odorant receptors S1 or MOR23.

Review 4. Axonal wiring in the mouse olfactory system.

5. A neuronal identity code for the odorant receptor-specific and activity-dependent axon sorting.

6. Mapping of class I and class II odorant receptors to glomerular domains by two distinct types of olfactory sensory neurons in the mouse.

7. Evidence for developmentally regulated local translation of odorant receptor mRNAs in the axons of olfactory sensory neurons.

Review 8. The structure and function of G-protein-coupled receptors.

9. Adenylyl cyclase-dependent axonal targeting in the olfactory system.

10. Absence of adenylyl cyclase 3 perturbs peripheral olfactory projections in mice.

1. Cell type-dependent axonal localization of translational regulators and mRNA in mouse peripheral olfactory neurons.

2. Homotypic and heterotypic adhesion induced by odorant receptors and the β2-adrenergic receptor.