Literature DB >> 23959139

Electrostatics and flexibility drive membrane recognition and early penetration by the antimicrobial peptide dendrimer bH1.

Harish K Ravi1, Michaela Stach, Thereza A Soares, Tamis Darbre, Jean-Louis Reymond, Michele Cascella.   

Abstract

Molecular dynamics simulations of the polycationic antimicrobial peptide dendrimer (Leu)8(DapLeu)4(DapPhe)2DapLys-NH2 binding to membranes suggest that electrostatic interactions with the polyanionic lipopolysaccharide (LPS) and conformational flexibility of the 2,3-diaminopropanoic acid (Dap) branching units drive its selective insertion into microbial membranes.

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Year:  2013        PMID： 23959139     DOI： 10.1039/c3cc44912b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Molecular dynamics modeling of Pseudomonas aeruginosa outer membranes.

Authors:  Ao Li; Jeffrey W Schertzer; Xin Yong
Journal:  Phys Chem Chem Phys       Date:  2018-09-19       Impact factor: 3.676

2.  New amphiphilic neamine derivatives active against resistant Pseudomonas aeruginosa and their interactions with lipopolysaccharides.

Authors:  Guillaume Sautrey; Louis Zimmermann; Magali Deleu; Alicia Delbar; Luiza Souza Machado; Katy Jeannot; Françoise Van Bambeke; Julien M Buyck; Jean-Luc Decout; Marie-Paule Mingeot-Leclercq
Journal:  Antimicrob Agents Chemother       Date:  2014-05-27       Impact factor: 5.191

3.  Modeling the electrostatic potential of asymmetric lipopolysaccharide membranes: the MEMPOT algorithm implemented in DelPhi.

Authors:  Roberta P Dias; Lin Lin; Thereza A Soares; Emil Alexov
Journal:  J Comput Chem       Date:  2014-05-06       Impact factor: 3.376

4.  Polymyxins induce lipid scrambling and disrupt the homeostasis of Gram-negative bacteria membrane.

Authors:  Lei Fu; Xiangyuan Li; Shan Zhang; Yi Dong; Weihai Fang; Lianghui Gao
Journal:  Biophys J       Date:  2022-08-13       Impact factor: 3.699

5.  In Vitro Activity of the Novel Antimicrobial Peptide Dendrimer G3KL against Multidrug-Resistant Acinetobacter baumannii and Pseudomonas aeruginosa.

Authors:  João Pires; Thissa N Siriwardena; Michaela Stach; Regula Tinguely; Sara Kasraian; Francesco Luzzaro; Stephen L Leib; Tamis Darbre; Jean-Louis Reymond; Andrea Endimiani
Journal:  Antimicrob Agents Chemother       Date:  2015-10-12       Impact factor: 5.191

6.  Interaction of the antimicrobial peptide polymyxin B1 with both membranes of E. coli: a molecular dynamics study.

Authors:  Nils A Berglund; Thomas J Piggot; Damien Jefferies; Richard B Sessions; Peter J Bond; Syma Khalid
Journal:  PLoS Comput Biol       Date:  2015-04-17       Impact factor: 4.475

7.  Chemical space guided discovery of antimicrobial bridged bicyclic peptides against Pseudomonas aeruginosa and its biofilms.

Authors:  Ivan Di Bonaventura; Xian Jin; Ricardo Visini; Daniel Probst; Sacha Javor; Bee-Ha Gan; Gaëlle Michaud; Antonino Natalello; Silvia Maria Doglia; Thilo Köhler; Christian van Delden; Achim Stocker; Tamis Darbre; Jean-Louis Reymond
Journal:  Chem Sci       Date:  2017-07-13       Impact factor: 9.825

Review 8.  Shedding light on the structural properties of lipid bilayers using molecular dynamics simulation: a review study.

Authors:  Sajad Moradi; Amin Nowroozi; Mohsen Shahlaei
Journal:  RSC Adv       Date:  2019-02-06       Impact factor: 4.036

9.  Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide.

Authors:  Xin Zhu; Zhi Ma; Jiajun Wang; Shuli Chou; Anshan Shan
Journal:  PLoS One       Date:  2014-12-10       Impact factor: 3.240
  9 in total

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