OBJECTIVES: The IVS7-2A>G (c.919-2A>G) and p.H723R (c.2168A>G) mutations of SLC26A4 gene are recognized as a risk factor for the non-syndromic hearing loss. To elucidate the variable results, a meta-analysis and systematic review was performed from all case-control studies by pooling data on them. METHODS: The case-control studies were assessed with a modification of the Newcastle-Ottawa Scale (NOS). The strength of association between c.919-2A>G, c.2168A>G and hearing loss risk was measured by odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS: We included 14 case-control studies and 16 case series studies in present study. There was a higher prevalence of the c.919-2A>G mutation in the case group than that in the control group (12.4% vs 0.9%; OR = 13.05, 95% CI: 8.41-20.23, Z = 11.47, P<0.00001). CONCLUSIONS: In conclusion, the results from this meta-analysis suggest that NSHL patients have an increased risk of the c.919-2A>G mutation of SLC26A4 gene in Asians, especially in Chinese.
OBJECTIVES: The IVS7-2A>G (c.919-2A>G) and p.H723R (c.2168A>G) mutations of SLC26A4 gene are recognized as a risk factor for the non-syndromic hearing loss. To elucidate the variable results, a meta-analysis and systematic review was performed from all case-control studies by pooling data on them. METHODS: The case-control studies were assessed with a modification of the Newcastle-Ottawa Scale (NOS). The strength of association between c.919-2A>G, c.2168A>G and hearing loss risk was measured by odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS: We included 14 case-control studies and 16 case series studies in present study. There was a higher prevalence of the c.919-2A>G mutation in the case group than that in the control group (12.4% vs 0.9%; OR = 13.05, 95% CI: 8.41-20.23, Z = 11.47, P<0.00001). CONCLUSIONS: In conclusion, the results from this meta-analysis suggest that NSHL patients have an increased risk of the c.919-2A>G mutation of SLC26A4 gene in Asians, especially in Chinese.
Authors: Alexander Y Сhurbanov; Tatiana M Karafet; Igor V Morozov; Valeriia Yu Mikhalskaia; Marina V Zytsar; Alexander A Bondar; Olga L Posukh Journal: PLoS One Date: 2016-04-15 Impact factor: 3.240
Authors: Yi Jiang; Shasha Huang; Tao Deng; Lihua Wu; Juan Chen; Dongyang Kang; Xiufeng Xu; Ruiyu Li; Dongyi Han; Pu Dai Journal: PLoS One Date: 2015-08-07 Impact factor: 3.240
Authors: Valeriia Yu Danilchenko; Marina V Zytsar; Ekaterina A Maslova; Marita S Bady-Khoo; Nikolay A Barashkov; Igor V Morozov; Alexander A Bondar; Olga L Posukh Journal: Diagnostics (Basel) Date: 2021-12-17