Literature DB >> 23958194

Examining the cognitive effects of a special extract of Bacopa monniera (CDRI08: Keenmnd): a review of ten years of research at Swinburne University.

Con Stough1, Andrew Scholey, Vanessa Cropley, Keith Wesnes, Andrea Zangara, Matthew Pase, Karen Savage, Karen Nolidin, Justine Lomas, Luke Downey.   

Abstract

Bacopa monniera (EBm), an Indian aquatic herb, has been used in traditional Ayurvedic medicine for centuries for indications related to memory and inflammation. More recently specific extracts of EBm have emerged that have been subjected to rigorous in vitro, animal and now human clinical trials. In this paper we discuss some of these studies with special reference to mechanisms and efficacy of a special extract of Bacopa (CDRI08). Studies using this extract indicate that CDRI08 has several modes of action on the human brain. Promising indications for use in humans include improving cognition in the elderly and in patients with neurodegenerative disorders.

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Year:  2013        PMID: 23958194     DOI: 10.18433/j35g6m

Source DB:  PubMed          Journal:  J Pharm Pharm Sci        ISSN: 1482-1826            Impact factor:   2.327


  5 in total

1.  The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain.

Authors:  Michelle D Nemetchek; Andrea A Stierle; Donald B Stierle; Diana I Lurie
Journal:  J Ethnopharmacol       Date:  2016-07-26       Impact factor: 4.360

Review 2.  Herbal Medicine for the Treatment of Vascular Dementia: An Overview of Scientific Evidence.

Authors:  Dennis Chang; Jianxun Liu; Kellie Bilinski; Li Xu; Genevieve Z Steiner; Sai W Seto; Alan Bensoussan
Journal:  Evid Based Complement Alternat Med       Date:  2016-12-27       Impact factor: 2.629

Review 3.  Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies.

Authors:  Aimi Syamima Abdul Manap; Shantini Vijayabalan; Priya Madhavan; Yoke Yin Chia; Aditya Arya; Eng Hwa Wong; Farzana Rizwan; Umesh Bindal; Shajan Koshy
Journal:  Drug Target Insights       Date:  2019-07-31

Review 4.  Molecular and Functional Characterization of Bacopa monniera: A Retrospective Review.

Authors:  Koilmani Emmanuvel Rajan; Jayakumar Preethi; Hemant K Singh
Journal:  Evid Based Complement Alternat Med       Date:  2015-08-27       Impact factor: 2.629

5.  Possible Involvement of Standardized Bacopa monniera Extract (CDRI-08) in Epigenetic Regulation of reelin and Brain-Derived Neurotrophic Factor to Enhance Memory.

Authors:  Jayakumar Preethi; Hemant K Singh; Koilmani E Rajan
Journal:  Front Pharmacol       Date:  2016-06-27       Impact factor: 5.810

  5 in total

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