Literature DB >> 2395806

Percutaneous absorption enhancement of an ionic molecule by ethanol-water systems in human skin.

T Kurihara-Bergstrom1, K Knutson, L J DeNoble, C Y Goates.   

Abstract

Ethanol-water systems enhance permeation of ionic solutes through human stratum corneum. Optimum enhancement of salicylate ion permeation has been observed with ethanol volume fractions near 0.63. The mechanism of action of ethanol-water systems enhancing skin permeation was investigated by in vitro skin permeation studies combined with Fourier transform infrared spectroscopy experiments. The increased skin permeation of the ionic permeant by the ethanol-water systems may be associated with alterations involving the polar pathway. Polar pathway alterations may occur in either or both the lipid polar head and proteinaceous regions of the stratum corneum. Ion-pair formation may also contribute to increased permeation. However, the decreased permeation of salicylate ion observed at higher volume fractions of ethanol may be attributed to decreased uptake of permeant into the stratum corneum.

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Year:  1990        PMID： 2395806     DOI： 10.1023/a:1015879925147

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  15 in total

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Authors:  R J Scheuplein
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6.  Effect of dipolar aprotic permeability enhancers on the basal stratum corneum.

Authors:  H H Sharata; R R Burnette
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7.  Interdigitated hydrocarbon chain packing causes the biphasic transition behavior in lipid/alcohol suspensions.

Authors:  S A Simon; T J McIntosh
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8.  Infrared absorption spectrum of keratin. II. Deuteration studies.

Authors:  E G Bendit
Journal:  Biopolymers       Date:  1966-06       Impact factor: 2.505

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Authors:  E G Bendit
Journal:  Biopolymers       Date:  1966-06       Impact factor: 2.505

10.  Solvent denaturation of proteins as observed by resolution-enhanced Fourier transform infrared spectroscopy.

Authors:  J M Purcell; H Susi
Journal:  J Biochem Biophys Methods       Date:  1984-07
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  21 in total

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Journal:  Pharm Res       Date:  1991-07       Impact factor: 4.200

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5.  Hindered diffusion of polar molecules through and effective pore radii estimates of intact and ethanol treated human epidermal membrane.

Authors:  K D Peck; A H Ghanem; W I Higuchi
Journal:  Pharm Res       Date:  1994-09       Impact factor: 4.200

6.  Flow-through system effects on in vitro analysis of transdermal systems.

Authors:  J Sclafani; J Nightingale; P Liu; T Kurihara-Bergstrom
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7.  The study of ultrasound and iontophoresis on oxaprozin transdermal penetration using surface-enhanced Raman spectroscopy.

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8.  Rate control in transdermal beta-estradiol reservoir membrane systems: the role of membrane and adhesive layer.

Authors:  R Altenburger; U D Rohr; T Kissel
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9.  Effect of some penetration enhancers on epithelial membrane lipid domains: evidence from fluorescence spectroscopy studies.

Authors:  T M Turunen; A Urtti; P Paronen; K L Audus; J H Rytting
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10.  Quantitative evaluation of aqueous isopropanol enhancement of skin flux of terbutaline (sulfate). I. Ion associations and species equilibria in the formulation.

Authors:  P Liu; T Kurihara-Bergstrom; F H Clarke; N Gonnella; W R Good
Journal:  Pharm Res       Date:  1992-08       Impact factor: 4.200
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