Literature DB >> 2395803

The metabolism of CGP-291: the use of microorganisms as models of mammalian metabolism.

T M Jürgens1, A M Clark.   

Abstract

CGP-291 is an investigational antiprotozoal agent with unknown metabolism. Microbial systems were utilized, as a model of mammalian metabolism, to predict the oxidative metabolic pathway of this nitroimidazole. Large-scale fermentation of CGP-291 with Beauvaria bassiana produced two major metabolites, IV and V. Structures of both were elucidated by comparing spectral data of metabolites to that of the starting material. The presence of two minor monohydroxylated metabolites was verified using LC-MS.

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Year:  1990        PMID： 2395803     DOI： 10.1023/a:1015871723330

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  8 in total

1.  Aerobic metabolism of niridazole by rat liver microsomes.

Authors:  J L Blumer; R F Novak; S V Lucas; J M Simpson; L T Webster
Journal:  Mol Pharmacol       Date:  1979-11       Impact factor: 4.436

2.  Reductive metabolism of niridazole by adult Schistosoma mansoni. Correlation with covalent drug binding to parasite macromolecules.

Authors:  J W Tracy; B A Catto; L T Webster
Journal:  Mol Pharmacol       Date:  1983-09       Impact factor: 4.436

3.  Isolation, characterization, and synthesis of an immunoregulatory metabolite of niridazole: 1-thiocarbamoyl-2-imidazolidinone.

Authors:  J W Tracy; E H Fairchild; S V Lucas; L T Webster
Journal:  Mol Pharmacol       Date:  1980-09       Impact factor: 4.436

4.  The metabolism of niridazole (AMBILHARR) in man. II. Investigations on patients suffering from clinically advanced forms of Schistosoma mansoni infection.

Authors:  J W Faigle; A D Coutinho; H Keberle; F Trindade Barretto
Journal:  Ann Trop Med Parasitol       Date:  1970-09

5.  The metabolism of niridazole (AMBILHARR) in man. I. Investigations on patients suffering from clinically mild forms of Schistosoma haematobium and Schistosoma mansoni infection.

Authors:  J W Faigle; D M Blair; V de V Clarke; L A Davidson; D C Dukes; H Keberle
Journal:  Ann Trop Med Parasitol       Date:  1970-09

6.  Primaquine: metabolism by microorganisms and 13C nuclear magnetic resonance assignments.

Authors:  A M Clark; C D Huford; J D McChesney
Journal:  Antimicrob Agents Chemother       Date:  1981-02       Impact factor: 5.191

Review 7.  The use of microorganisms for the study of drug metabolism.

Authors:  A M Clark; J D McChesney; C D Hufford
Journal:  Med Res Rev       Date:  1985 Apr-Jun       Impact factor: 12.944

8.  Microbial models of mammalian metabolism: stereospecificity of ketone reduction with pentoxifylline.

Authors:  P J Davis; S K Yang; R V Smith
Journal:  Xenobiotica       Date:  1985-12       Impact factor: 1.908
  8 in total
  1 in total

1.  Intramembranous bone healing process subsequent to tooth extraction in mice: micro-computed tomography, histomorphometric and molecular characterization.

Authors:  Andreia Espindola Vieira; Carlos Eduardo Repeke; Samuel de Barros Ferreira Junior; Priscila Maria Colavite; Claudia Cristina Biguetti; Rodrigo Cardoso Oliveira; Gerson Francisco Assis; Rumio Taga; Ana Paula Favaro Trombone; Gustavo Pompermaier Garlet
Journal:  PLoS One       Date:  2015-05-29       Impact factor: 3.240
  1 in total

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