| Literature DB >> 23957534 |
Yuyun Zhao1, Zeliang Chen, Yanfen Chen, Jie Xu, Jinghong Li, Xingyu Jiang.
Abstract
Co-presenting non-antibiotic drugs and pyrimidinethiol on gold nanoparticles (NPs) can generate broad-spectrum antibacterial and bactericidal activities against superbugs. Dimethylbiguanide (metformin), an anti-hyperglycemic drug, shows the best enhanced activity via increasing the ability to compromise bacterial cell walls. Synergistic effects are also reflected in the eradicating biofilm cells. Our findings suggest a large chemical space to develop new antibacterial materials to treat superbugs.Entities:
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Year: 2013 PMID： 23957534 DOI： 10.1021/ja4058635
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419