| Literature DB >> 23957502 |
Ran Li1, Xuemei Wang, Zhibin Wei, Chunrui Wu, Feng Shi.
Abstract
The reaction of arynes with vinylogous amides containing no free N-H bonds proceeds in a [2 + 2] cycloaddition fashion at ambient temperature. The electronic properties of the vinylogous amides allow for the cycloadducts undergoing a facile ring-opening process, leading to electronically biased ortho-quinodimethide intermediates. Subsequent nucleophilic addition with alcohols affords 2-substituted benzaldehydes or ketones.Entities:
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Year: 2013 PMID： 23957502 DOI： 10.1021/ol4018968
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005