OBJECTIVES: The aim of this study was to determine the prevalence of frailty in a community cohort of patients with heart failure (HF) and to determine whether frailty is associated with healthcare utilization. BACKGROUND: Frailty is associated with death in patients with HF, but its prevalence and impact on healthcare utilization in patients with HF are poorly characterized. METHODS: Residents of Olmsted, Dodge, and Fillmore counties in Minnesota with HF between October 2007 and March 2011 were prospectively recruited to undergo frailty assessment. Frailty was defined as 3 or more of the following: unintentional weight loss, exhaustion, weak grip strength, and slowness and low physical activity measured by the SF-12 physical component score. Intermediate frailty was defined as 1 or 2 components. Negative binomial regression was used to examine the association between outpatient visits and frailty; Andersen-Gill models were used to determine if frailty predicted emergency department (ED) visits or hospitalizations. RESULTS: Among 448 patients (mean age 73 ± 13 years, 57% men), 74% had some degree of frailty (19% frail, 55% intermediate frail). Over a mean follow-up period of 2.0 ± 1.1 years, 20,164 outpatient visits, 1,440 ED visits, and 1,057 hospitalizations occurred. After adjustment for potential confounders, frailty was associated with a 92% increased risk for ED visits and a 65% increased risk for hospitalizations. The population-attributable risk associated with any degree of frailty was 35% for ED visits and 19% for hospitalizations. CONCLUSIONS: Frailty is common among community patients with HF and is a strong and independent predictor of ED visits and hospitalizations. Because frailty is potentially modifiable, it should be incorporated in the clinical evaluation of patients with HF.
OBJECTIVES: The aim of this study was to determine the prevalence of frailty in a community cohort of patients with heart failure (HF) and to determine whether frailty is associated with healthcare utilization. BACKGROUND: Frailty is associated with death in patients with HF, but its prevalence and impact on healthcare utilization in patients with HF are poorly characterized. METHODS: Residents of Olmsted, Dodge, and Fillmore counties in Minnesota with HF between October 2007 and March 2011 were prospectively recruited to undergo frailty assessment. Frailty was defined as 3 or more of the following: unintentional weight loss, exhaustion, weak grip strength, and slowness and low physical activity measured by the SF-12 physical component score. Intermediate frailty was defined as 1 or 2 components. Negative binomial regression was used to examine the association between outpatient visits and frailty; Andersen-Gill models were used to determine if frailty predicted emergency department (ED) visits or hospitalizations. RESULTS: Among 448 patients (mean age 73 ± 13 years, 57% men), 74% had some degree of frailty (19% frail, 55% intermediate frail). Over a mean follow-up period of 2.0 ± 1.1 years, 20,164 outpatient visits, 1,440 ED visits, and 1,057 hospitalizations occurred. After adjustment for potential confounders, frailty was associated with a 92% increased risk for ED visits and a 65% increased risk for hospitalizations. The population-attributable risk associated with any degree of frailty was 35% for ED visits and 19% for hospitalizations. CONCLUSIONS: Frailty is common among community patients with HF and is a strong and independent predictor of ED visits and hospitalizations. Because frailty is potentially modifiable, it should be incorporated in the clinical evaluation of patients with HF.
Authors: L P Fried; C M Tangen; J Walston; A B Newman; C Hirsch; J Gottdiener; T Seeman; R Tracy; W J Kop; G Burke; M A McBurnie Journal: J Gerontol A Biol Sci Med Sci Date: 2001-03 Impact factor: 6.053
Authors: Daniel E Forman; Michael W Rich; Karen P Alexander; Susan Zieman; Mathew S Maurer; Samer S Najjar; Joseph C Cleveland; Harlan M Krumholz; Nanette K Wenger Journal: J Am Coll Cardiol Date: 2011-05-03 Impact factor: 24.094
Authors: Mandeep Singh; Karen Alexander; Veronique L Roger; Charanjit S Rihal; Heather E Whitson; Amir Lerman; Arschad Jahangir; K Sreekumaran Nair Journal: Mayo Clin Proc Date: 2008-10 Impact factor: 7.616
Authors: Christopher M O'Connor; David J Whellan; Kerry L Lee; Steven J Keteyian; Lawton S Cooper; Stephen J Ellis; Eric S Leifer; William E Kraus; Dalane W Kitzman; James A Blumenthal; David S Rendall; Nancy Houston Miller; Jerome L Fleg; Kevin A Schulman; Robert S McKelvie; Faiez Zannad; Ileana L Piña Journal: JAMA Date: 2009-04-08 Impact factor: 56.272
Authors: Gordon R Reeves; David J Whellan; Pamela Duncan; Christopher M O'Connor; Amy M Pastva; Joel D Eggebeen; Leigh Ann Hewston; Timothy M Morgan; Shelby D Reed; W Jack Rejeski; Robert J Mentz; Paul B Rosenberg; Dalane W Kitzman Journal: Am Heart J Date: 2016-12-28 Impact factor: 4.749
Authors: Yijun Shao; April F Mohanty; Ali Ahmed; Charlene R Weir; Bruce E Bray; Rashmee U Shah; Douglas Redd; Qing Zeng-Treitler Journal: AMIA Annu Symp Proc Date: 2017-02-10
Authors: Haider J Warraich; Dalane W Kitzman; David J Whellan; Pamela W Duncan; Robert J Mentz; Amy M Pastva; M Benjamin Nelson; Bharathi Upadhya; Gordon R Reeves Journal: Circ Heart Fail Date: 2018-11 Impact factor: 8.790
Authors: Quin E Denfeld; Kerri Winters-Stone; James O Mudd; Jill M Gelow; Sawsan Kurdi; Christopher S Lee Journal: Int J Cardiol Date: 2017-02-10 Impact factor: 4.164
Authors: Robert J Mentz; Jacob P Kelly; Thomas G von Lueder; Adriaan A Voors; Carolyn S P Lam; Martin R Cowie; Keld Kjeldsen; Ewa A Jankowska; Dan Atar; Javed Butler; Mona Fiuzat; Faiez Zannad; Bertram Pitt; Christopher M O'Connor Journal: J Am Coll Cardiol Date: 2014-11-24 Impact factor: 24.094
Authors: Jeremy Walston; Thomas N Robinson; Susan Zieman; Frances McFarland; Christopher R Carpenter; Keri N Althoff; Melissa K Andrew; Caroline S Blaum; Patrick J Brown; Brian Buta; E Wesley Ely; Luigi Ferrucci; Kevin P High; Stephen B Kritchevsky; Kenneth Rockwood; Kenneth E Schmader; Felipe Sierra; Kaycee M Sink; Ravi Varadhan; Arti Hurria Journal: J Am Geriatr Soc Date: 2017-04-19 Impact factor: 5.562
Authors: Sheila M McNallan; Alanna M Chamberlain; Yariv Gerber; Mandeep Singh; Robert L Kane; Susan A Weston; Shannon M Dunlay; Ruoxiang Jiang; Véronique L Roger Journal: Am Heart J Date: 2013-09-17 Impact factor: 4.749
Authors: Sheila M Manemann; Alanna M Chamberlain; Cynthia M Boyd; Donna M Miller; Kimberly L Poe; Andrea Cheville; Susan A Weston; Ellen E Koepsell; Ruoxiang Jiang; Véronique L Roger Journal: Circ Cardiovasc Qual Outcomes Date: 2018-08