BACKGROUND: We aimed to assess the associations between occupational exposure to cleaning products, a gender-related exposure, and asthma characteristics, considering clinical, immunological and inflammatory aspects. METHODS: Analyses were conducted in 391 women (73 with adult-onset asthma) from the follow-up of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). Occupational exposure to cleaning/disinfecting products was estimated using the asthma-specific job-exposure-matrix (44 women exposed). RESULTS: Occupational exposures were associated with more symptomatic asthma (odds ratio (95% CI): 2.8(1.2-6.4)) and severe asthma (5.1(1.7-15.3)). An association was suggested for poorly controlled asthma (2.2(0.9-5.5)). Associations were observed for asthma without positive skin prick test (3.0(1.1-8.3)), with a low IgE level (2.8(1.2-6.2)), and with a low eosinophil count (3.2(1.5-7.1)). CONCLUSIONS: Results strengthen the evidence of a deleterious role of cleaning products in asthma and are consistent with the hypothesis of non-allergic mechanisms in relation to workplace cleaning exposures.
BACKGROUND: We aimed to assess the associations between occupational exposure to cleaning products, a gender-related exposure, and asthma characteristics, considering clinical, immunological and inflammatory aspects. METHODS: Analyses were conducted in 391 women (73 with adult-onset asthma) from the follow-up of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). Occupational exposure to cleaning/disinfecting products was estimated using the asthma-specific job-exposure-matrix (44 women exposed). RESULTS: Occupational exposures were associated with more symptomatic asthma (odds ratio (95% CI): 2.8(1.2-6.4)) and severe asthma (5.1(1.7-15.3)). An association was suggested for poorly controlled asthma (2.2(0.9-5.5)). Associations were observed for asthma without positive skin prick test (3.0(1.1-8.3)), with a low IgE level (2.8(1.2-6.2)), and with a low eosinophil count (3.2(1.5-7.1)). CONCLUSIONS: Results strengthen the evidence of a deleterious role of cleaning products in asthma and are consistent with the hypothesis of non-allergic mechanisms in relation to workplace cleaning exposures.
Authors: Orianne Dumas; Krislyn M Boggs; Catherine Quinot; Raphaëlle Varraso; Jan-Paul Zock; Paul K Henneberger; Frank E Speizer; Nicole Le Moual; Carlos A Camargo Journal: Am J Ind Med Date: 2019-11-06 Impact factor: 2.214
Authors: Orianne Dumas; Aleta S Wiley; Paul K Henneberger; Frank E Speizer; Jan-Paul Zock; Raphaëlle Varraso; Nicole Le Moual; Krislyn M Boggs; Carlos A Camargo Journal: Am J Ind Med Date: 2016-11-15 Impact factor: 2.214
Authors: Orianne Dumas; Raphaëlle Varraso; Jan Paul Zock; Paul K Henneberger; Frank E Speizer; Aleta S Wiley; Nicole Le Moual; Carlos A Camargo Journal: Occup Environ Med Date: 2015-02-24 Impact factor: 4.402
Authors: Orianne Dumas; Aleta S Wiley; Catherine Quinot; Raphaëlle Varraso; Jan-Paul Zock; Paul K Henneberger; Frank E Speizer; Nicole Le Moual; Carlos A Camargo Journal: Eur Respir J Date: 2017-10-05 Impact factor: 16.671
Authors: Kristina W Whitworth; Brenda Berumen-Flucker; George L Delclos; Sonia Fragoso; Claudia Mata; David Gimeno Ruiz de Porras Journal: Arch Environ Occup Health Date: 2019-04-29 Impact factor: 1.663