| Literature DB >> 23955491 |
Bing Zhou1, Fangzhen Yuan, Zhong He, Changlian Tan.
Abstract
This study investigates changes in substantia nigra metabolites in Parkinson's disease (PD) using proton magnetic resonance spectroscopy ((1)H- MRS). Thirty patients with asymmetric PD and 20 normal controls were included in this study. Substantia nigra metabolites were detected in all subjects using 3D-multimer (1)H-MRS with a 3.0 T MRI scanner. The relative ratios of NAA/Cr, NAA/Cho, NAA/(Cho + Cr) in the substantia nigra were compared between two sides of asymmetric PD patients as well as between PD patients and controls. Significant differences in NAA/Cr, NAA/Cho, NAA/(Cho + Cr) were observed between PD patients and healthy controls (P < 0.05) as well as between the ipsilateral and contralateral of affected extremity in PD patients (P < 0.05). Significant differences in NAA/Cr, NAA/Cho, NAA/(Cho + Cr) were also observed between patients with mild and severe PD. Thus, we found that (1)H-MRS can be used to detect substantia nigra metabolites in PD patients, which may be useful for early diagnosis and evaluation of PD.Entities:
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Year: 2014 PMID： 23955491 DOI： 10.1007/s11682-013-9251-2
Source DB: PubMed Journal: Brain Imaging Behav ISSN： 1931-7557 Impact factor: 3.978