OBJECTIVES: To evaluate the association of microsatellite instability (MSI) with clinicopathologic features and oncologic outcomes in patients with poorly differentiated colorectal cancer (PD). METHODS: Study patients were divided into well-differentiated colorectal cancer (WD) and PD, which were compared according to histologic differentiation and MSI status. RESULTS: Among 1,941 patients, PD was more frequent among microsatellite-unstable tumors (23.6%) than among microsatellite-stable (MSS) tumors (4.2%, P < .001). Patients with PD had worse 4-year overall survival rates than patients with WD (78.6% vs 88.2%, P = 0.010). Compared with MSS-PD tumors, MSI-PD tumors were characterized by right-colon predilection, larger size, and infrequent lymph node metastasis (P < .001 to P = .007). CONCLUSIONS: The clinicopathologic characteristics of PD were closely associated with those of MSI. The outcomes of MSI-PD tumors were better than those of MSS-PD tumors, but this finding did not reach statistical significance.
OBJECTIVES: To evaluate the association of microsatellite instability (MSI) with clinicopathologic features and oncologic outcomes in patients with poorly differentiated colorectal cancer (PD). METHODS: Study patients were divided into well-differentiated colorectal cancer (WD) and PD, which were compared according to histologic differentiation and MSI status. RESULTS: Among 1,941 patients, PD was more frequent among microsatellite-unstable tumors (23.6%) than among microsatellite-stable (MSS) tumors (4.2%, P < .001). Patients with PD had worse 4-year overall survival rates than patients with WD (78.6% vs 88.2%, P = 0.010). Compared with MSS-PD tumors, MSI-PD tumors were characterized by right-colon predilection, larger size, and infrequent lymph node metastasis (P < .001 to P = .007). CONCLUSIONS: The clinicopathologic characteristics of PD were closely associated with those of MSI. The outcomes of MSI-PD tumors were better than those of MSS-PD tumors, but this finding did not reach statistical significance.
Authors: F Jeroen Vogelaar; Felice N van Erning; Marlies S Reimers; Hans van der Linden; Hans Pruijt; Adriaan J C van den Brule; Koop Bosscha Journal: Mol Med Date: 2016-05-09 Impact factor: 6.354
Authors: Lennard Y W Lee; Connor Woolley; Thomas Starkey; Sujata Biswas; Tia Mirshahi; Chiara Bardella; Stefania Segditsas; Shazia Irshad; Ian Tomlinson Journal: Clin Cancer Res Date: 2018-10-15 Impact factor: 12.531
Authors: Lik Hang Lee; Rhonda K Yantiss; Eran Sadot; Bing Ren; Marcela Santos Calvacanti; Jaclyn F Hechtman; Sinisa Ivelja; Be Huynh; Yue Xue; Tatiana Shitilbans; Hamza Guend; Zsofia K Stadler; Martin R Weiser; Efsevia Vakiani; Mithat Gönen; David S Klimstra; Jinru Shia Journal: Hum Pathol Date: 2016-12-26 Impact factor: 3.466
Authors: Shannon D McClintock; Justin A Colacino; Durga Attili; Michael K Dame; Aliah Richter; Anusha R Reddy; Venkatesha Basrur; Areeba H Rizvi; D Kim Turgeon; James Varani; Muhammad N Aslam Journal: Cancer Prev Res (Phila) Date: 2018-04-10