Literature DB >> 2395528

Localization of m5 muscarinic receptor mRNA in rat brain examined by in situ hybridization histochemistry.

M T Vilaró1, J M Palacios, G Mengod.   

Abstract

The regional distribution of mRNA coding for the m5 muscarinic acetylcholine receptor subtype was investigated in tissue sections of rat brain by in situ hybridization histochemistry. The highest hybridization signal was observed in the hippocampus, but restricted to the ventral subiculum, pyramidal cells of the CA1 and, with lower intensity, of the CA2 subfields. Significant levels of hybridization were also seen in the substantia nigra pars compacta, ventral tegmental area, lateral habenula, ventromedial hypothalamic nucleus and mammillary bodies. An involvement of the m5 muscarinic receptors in the regulation of the dopaminergic nigrostriatal pathway is suggested.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2395528     DOI： 10.1016/0304-3940(90)90064-g

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  63 in total

1.  Muscarinic tone sustains impulse flow in the septohippocampal GABA but not cholinergic pathway: implications for learning and memory.

Authors:  M Alreja; M Wu; W Liu; J B Atkins; C Leranth; M Shanabrough
Journal:  J Neurosci       Date:  2000-11-01       Impact factor: 6.167

2.  Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice.

Authors:  M Yamada; K G Lamping; A Duttaroy; W Zhang; Y Cui; F P Bymaster; D L McKinzie; C C Felder; C X Deng; F M Faraci; J Wess
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-13       Impact factor: 11.205

Review 3.  Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia.

Authors:  Carrie K Jones; Nellie Byun; Michael Bubser
Journal:  Neuropsychopharmacology       Date:  2011-09-28       Impact factor: 7.853

Review 4.  The antipsychotic potential of muscarinic allosteric modulation.

Authors:  Thomas M Bridges; Evan P LeBois; Corey R Hopkins; Michael R Wood; Carrie K Jones; P Jeffrey Conn; Craig W Lindsley
Journal:  Drug News Perspect       Date:  2010-05

5.  Distinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain.

Authors:  S Sugita; N Uchimura; Z G Jiang; R A North
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

6.  Behavioral effects of morphine and cocaine in M1 muscarinic acetylcholine receptor-deficient mice.

Authors:  Kelly A Carrigan; Linda A Dykstra
Journal:  Psychopharmacology (Berl)       Date:  2007-01-09       Impact factor: 4.530

7.  Muscarinic acetylcholine receptor subtype expression in avian vestibular hair cells, nerve terminals and ganglion cells.

Authors:  G Q Li; G A Kevetter; R B Leonard; D J Prusak; T G Wood; M J Correia
Journal:  Neuroscience       Date:  2007-03-27       Impact factor: 3.590

8.  Promoter IV-BDNF deficiency disturbs cholinergic gene expression of CHRNA5, CHRM2, and CHRM5: effects of drug and environmental treatments.

Authors:  Kazuko Sakata; Abigail E Overacre
Journal:  J Neurochem       Date:  2017-08-16       Impact factor: 5.372

9.  Affective analgesia following muscarinic activation of the ventral tegmental area in rats.

Authors:  Robert G Kender; Steven E Harte; Elizabeth M Munn; George S Borszcz
Journal:  J Pain       Date:  2008-04-03       Impact factor: 5.820

10.  Muscarinic acetylcholine receptor binding affinities of pethidine analogs.

Authors:  Na-Ra Lee; Xuan Zhang; Mahesh Darna; Linda P Dwoskin; Guangrong Zheng
Journal:  Bioorg Med Chem Lett       Date:  2015-10-19       Impact factor: 2.823
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.