Literature DB >> 23954291

Influenza NS1 interacts with p53 and alters its binding to p53-responsive genes, in a promoter-dependent manner.

Olivier Terrier1, Audrey Diederichs, Julia Dubois, Gaëlle Cartet, Bruno Lina, Jean-Christophe Bourdon, Manuel Rosa-Calatrava.   

Abstract

The interplay between influenza A viruses (IAV) and p53 has only been reported in a limited number of studies, mainly focusing on the antiviral role of p53. We investigated the impact of IAV infection on p53 stability and transcriptional activity. Our results indicate that IAV-induced stabilization of p53 only partially correlates with modulation of p53 transcriptional activity measured during infection. Moreover, we show that the viral non-structural protein 1 (NS1) is able to inhibit p53 transcriptional activity, in a promoter-dependent manner. Based on these data, we propose that NS1 may contribute to p53-mediated cell fate decision during IAV infection.
Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Influenza virus; Non-structural protein NS1; Orthomyxoviridae; Transcription factor; p53

Mesh：

Substances：

Year:  2013        PMID： 23954291     DOI： 10.1016/j.febslet.2013.08.006

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  The Nonstructural NS1 Protein of Influenza Viruses Modulates TP53 Splicing through Host Factor CPSF4.

Authors:  Manuel Rosa-Calatrava; Olivier Terrier; Julia Dubois; Aurélien Traversier; Thomas Julien; Blandine Padey; Bruno Lina; Jean-Christophe Bourdon; Virginie Marcel; Guy Boivin
Journal:  J Virol       Date:  2019-03-21       Impact factor: 5.103

Review 2.  p53 Isoforms: Key Regulators of the Cell Fate Decision.

Authors:  Sebastien M Joruiz; Jean-Christophe Bourdon
Journal:  Cold Spring Harb Perspect Med       Date:  2016-08-01       Impact factor: 6.915

3.  Non-structural protein 1 of H3N2 influenza A virus induces nucleolar stress via interaction with nucleolin.

Authors:  Yinxia Yan; Yongming Du; Gefei Wang; Kangsheng Li
Journal:  Sci Rep       Date:  2017-12-19       Impact factor: 4.379

Review 4.  40 Years of Research Put p53 in Translation.

Authors:  Virginie Marcel; Flora Nguyen Van Long; Jean-Jacques Diaz
Journal:  Cancers (Basel)       Date:  2018-05-21       Impact factor: 6.639

5.  Meeting report: 4th ISIRV antiviral group conference: Novel antiviral therapies for influenza and other respiratory viruses.

Authors:  Jennifer L McKimm-Breschkin; Alicia M Fry
Journal:  Antiviral Res       Date:  2016-02-09       Impact factor: 5.970

Review 6.  How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity.

Authors:  Laurie-Anne Lamotte; Lionel Tafforeau
Journal:  Viruses       Date:  2021-11-19       Impact factor: 5.048

7.  TP53 Gene Therapy as a Potential Treatment for Patients with COVID-19.

Authors:  Joe B Harford; Sang Soo Kim; Kathleen F Pirollo; Esther H Chang
Journal:  Viruses       Date:  2022-03-31       Impact factor: 5.818

Review 8.  Uncovering the role of p53 splice variants in human malignancy: a clinical perspective.

Authors:  Sylvanie Surget; Marie P Khoury; Jean-Christophe Bourdon
Journal:  Onco Targets Ther       Date:  2013-12-19       Impact factor: 4.147

9.  Nucleolin interacts with influenza A nucleoprotein and contributes to viral ribonucleoprotein complexes nuclear trafficking and efficient influenza viral replication.

Authors:  Olivier Terrier; Coralie Carron; Benoît De Chassey; Julia Dubois; Aurélien Traversier; Thomas Julien; Gaëlle Cartet; Anaïs Proust; Sabine Hacot; Denis Ressnikoff; Vincent Lotteau; Bruno Lina; Jean-Jacques Diaz; Vincent Moules; Manuel Rosa-Calatrava
Journal:  Sci Rep       Date:  2016-07-04       Impact factor: 4.379

10.  Influenza A viruses alter the stability and antiviral contribution of host E3-ubiquitin ligase Mdm2 during the time-course of infection.

Authors:  Andrés Pizzorno; Julia Dubois; Daniela Machado; Gaëlle Cartet; Aurelien Traversier; Thomas Julien; Bruno Lina; Jean-Christophe Bourdon; Manuel Rosa-Calatrava; Olivier Terrier
Journal:  Sci Rep       Date:  2018-02-27       Impact factor: 4.379
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.