OBJECTIVE: To analyze the effect of a community-based, poster-focused prevention program on the frequency of diabetic ketoacidosis (DKA) at diabetes onset in Austria. STUDY DESIGN: All newly diagnosed patients with diabetes ≤ 15 years of age were registered prospectively by the Austrian Diabetes Incidence Study Group. Registered data included initial blood glucose, pH, and ketonuria. DKA was defined as pH < 7.3 and severe DKA as pH < 7.1. Data between 1989 and 2011 were available. In autumn, 2009, a community-based prevention program similar to the Parma Campaign, in which posters were dispensed broadly, was initiated. The frequency of DKA at the onset of diabetes in the years 2005-2009 and 2010-2011 was compared. RESULTS: During the study period, 4038 children were registered. A total of 37.2% presented with DKA; 26% had a mild and 11.2% a severe form. The frequency of DKA was negatively associated with age at onset. In the years before the intervention program, 26% had mild DKA compared with 27% after the intervention (not significant). The prevalence of severe DKA in the years before the campaign was 12% compared with 9.5% thereafter (not significant). No significant change in the DKA rate at onset by the prevention program could be found when we compared age groups <5, 5 to <10, and 10 to <15 years, neither for mild nor for severe DKA. CONCLUSION: The frequency of DKA in children with newly diagnosed type 1 diabetes in Austria is high and did not change despite the efforts of a community-based information program.
OBJECTIVE: To analyze the effect of a community-based, poster-focused prevention program on the frequency of diabetic ketoacidosis (DKA) at diabetes onset in Austria. STUDY DESIGN: All newly diagnosed patients with diabetes ≤ 15 years of age were registered prospectively by the Austrian Diabetes Incidence Study Group. Registered data included initial blood glucose, pH, and ketonuria. DKA was defined as pH < 7.3 and severe DKA as pH < 7.1. Data between 1989 and 2011 were available. In autumn, 2009, a community-based prevention program similar to the Parma Campaign, in which posters were dispensed broadly, was initiated. The frequency of DKA at the onset of diabetes in the years 2005-2009 and 2010-2011 was compared. RESULTS: During the study period, 4038 children were registered. A total of 37.2% presented with DKA; 26% had a mild and 11.2% a severe form. The frequency of DKA was negatively associated with age at onset. In the years before the intervention program, 26% had mild DKA compared with 27% after the intervention (not significant). The prevalence of severe DKA in the years before the campaign was 12% compared with 9.5% thereafter (not significant). No significant change in the DKA rate at onset by the prevention program could be found when we compared age groups <5, 5 to <10, and 10 to <15 years, neither for mild nor for severe DKA. CONCLUSION: The frequency of DKA in children with newly diagnosed type 1 diabetes in Austria is high and did not change despite the efforts of a community-based information program.
Authors: Wei Peng; Jinna Yuan; Valentina Chiavaroli; Guanping Dong; Ke Huang; Wei Wu; Rahim Ullah; Binghan Jin; Hu Lin; José G B Derraik; Junfen Fu Journal: Front Endocrinol (Lausanne) Date: 2021-04-27 Impact factor: 5.555
Authors: Agnieszka Szypowska; Anna Ramotowska; Monika Grzechnik-Gryziak; Wojciech Szypowski; Anna Pasierb; Katarzyna Piechowiak Journal: J Diabetes Res Date: 2015-12-13 Impact factor: 4.011
Authors: Craig Jefferies; Samuel W Cutfield; José G B Derraik; Jignal Bhagvandas; Benjamin B Albert; Paul L Hofman; Alistair J Gunn; Wayne S Cutfield Journal: Sci Rep Date: 2015-05-19 Impact factor: 4.379
Authors: Hugo Segerer; Michael Wurm; Julia M Grimsmann; Beate Karges; Andreas Neu; Marina Sindichakis; Katharina Warncke; Axel Dost; Reinhard W Holl Journal: Dtsch Arztebl Int Date: 2021-06-04 Impact factor: 5.594
Authors: Stefano Zucchini; Andrea E Scaramuzza; Riccardo Bonfanti; Pietro Buono; Francesca Cardella; Vittoria Cauvin; Valentino Cherubini; Giovanni Chiari; Giuseppe d'Annunzio; Anna Paola Frongia; Dario Iafusco; Giulio Maltoni; Ippolita Patrizia Patera; Sonia Toni; Stefano Tumini; Ivana Rabbone Journal: J Diabetes Res Date: 2015-11-15 Impact factor: 4.011