Histomorphology of the hamster cheek pouch.

Histomorphology of the cheek pouch was studied in 14 hamsters by light and transmission electron microscopy. The cheek pouch wall was devoid of any lymphatic tissue and dense subepithelial tissue (i.e. the lamina propria) would render lymph drainage almost impossible and might constitute impermeable morphological barrier for non-recognition of transplants evoking a host immune response. Because in the literature it was reported that there is absence of any arteriovenous anastomoses on the pouch wall, and interruption of arterial supply failed to alter the growth rate of tissue grafts, we speculated that epidermal growth factors present in the saliva could play a role in maintaining the growth of tissue transplants.