Literature DB >> 2395163

Cancer family syndrome: cytogenetic investigations, in vitro tetraploidy, and biomarker studies in a large family.

G Guanti1, F Susca, G Cristofaro, M L Caruso, S Massari, R Porsia, A Stella, I Giorgio.   

Abstract

Fifty-five members of a family with the cancer family syndrome (CFS) were investigated for the following potential biomarkers for cancer proneness: (1) cytogenetics of peripheral blood lymphocytes and skin fibroblasts; (2) in vitro tetraploidy of dermal fibroblast monolayer cultures; (3) quantitative serum immunoglobulin determinations; (4) study of genetic linkage with respect to eight blood group markers including Kidd. Biological specimens were obtained from 14 patients affected with cancer, 21 subjects at risk, and 20 healthy subjects. None of the markers tested in this family, in order to identify a biomarker for the status of CFS gene carrier, was found to be useful. Our search for linkage to other biological markers (DNA RFLPs and NK cells) is in progress.

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Year:  1990        PMID： 2395163      PMCID： PMC1017182          DOI： 10.1136/jmg.27.7.441

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  10 in total

1.  Classification of qh regions in human chromosomes 1, 9, and 16 by C-banding.

Authors:  S R Patil; H A Lubs
Journal:  Hum Genet       Date:  1977-08-31       Impact factor: 4.132

2.  Expression of recessive alleles by chromosomal mechanisms in retinoblastoma.

Authors:  W K Cavenee; T P Dryja; R A Phillips; W F Benedict; R Godbout; B L Gallie; A L Murphree; L C Strong; R L White
Journal:  Nature       Date:  1983 Oct 27-Nov 2       Impact factor: 49.962

3.  Localization of the gene for familial adenomatous polyposis on chromosome 5.

Authors:  W F Bodmer; C J Bailey; J Bodmer; H J Bussey; A Ellis; P Gorman; F C Lucibello; V A Murday; S H Rider; P Scambler
Journal:  Nature       Date:  1987 Aug 13-19       Impact factor: 49.962

4.  Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). I. Clinical description of resource.

Authors:  H T Lynch; W Kimberling; W A Albano; J F Lynch; K Biscone; G S Schuelke; A A Sandberg; M Lipkin; E E Deschner; Y B Mikol
Journal:  Cancer       Date:  1985-08-15       Impact factor: 6.860

5.  Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). II. Biomarker studies.

Authors:  H T Lynch; G S Schuelke; W J Kimberling; W A Albano; J F Lynch; K A Biscone; M L Lipkin; E E Deschner; Y B Mikol; A A Sandberg
Journal:  Cancer       Date:  1985-08-15       Impact factor: 6.860

6.  Gardner syndrome in a man with an interstitial deletion of 5q.

Authors:  L Herrera; S Kakati; L Gibas; E Pietrzak; A A Sandberg
Journal:  Am J Med Genet       Date:  1986-11

7.  Retinoblastoma and subband deletion of chromosome 13.

Authors:  J J Yunis; N Ramsay
Journal:  Am J Dis Child       Date:  1978-02

8.  Cytogenetic study of patients with carcinoma of the colon and rectum: particular C-band variants as possible markers for cancer proneness.

Authors:  F Shabtai; E Antebi; D Klar; D Kimchi; J Hart; I Halbrecht
Journal:  Cancer Genet Cytogenet       Date:  1985-01-15

9.  Depressed level of natural killer cells in cancer family syndrome.

Authors:  G Guanti; S Massari; G Cristofaro; M L Caruso; R Porsia; A Stella; F Susca; A Tauro; I Giorgio
Journal:  Cancer Immunol Immunother       Date:  1989       Impact factor: 6.968

Review 10.  A review of hereditary malignant melanoma including biomarkers in familial atypical multiple mole melanoma syndrome.

Authors:  H T Lynch; R M Fusaro; B S Danes; W J Kimberling; J F Lynch
Journal:  Cancer Genet Cytogenet       Date:  1983-04
  10 in total
  1 in total

1.  Abnormal vascular network complexity: a new phenotypic marker in hereditary non-polyposis colorectal cancer syndrome.

Authors:  C De Felice; G Latini; G Bianciardi; S Parrini; G M Fadda; M Marini; R N Laurini; R J Kopotic
Journal:  Gut       Date:  2003-12       Impact factor: 23.059
  1 in total

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