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Literature DB >> 23951387

Perspectives of gene combinations in phenotype presentation.

Abstract

Cells exhibit a variety of phenotypes in different stages and diseases. Although several markers for cellular phenotypes have been identified, gene combinations denoting cellular phenotypes have not been completely elucidated. Recent advances in gene analysis have revealed that various gene expression patterns are observed in each cell species and status. In this review, the perspectives of gene combinations in cellular phenotype presentation are discussed. Gene expression profiles change during cellular processes, such as cell proliferation, cell differentiation, and cell death. In addition, epigenetic regulation increases the complexity of the gene expression profile. The role of gene combinations and panels of gene combinations in each cellular condition are also discussed.

Keywords: Cancer stem cell; Cellular phenotype; Gene combination; Gene expression; Stem cell

Year: 2013 PMID： 23951387 PMCID： PMC3744131 DOI： 10.4252/wjsc.v5.i3.61

Source DB: PubMed Journal: World J Stem Cells ISSN： 1948-0210 Impact factor: 5.326

74 in total

1. Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.

Authors: Toshinobu Nishimura; Shin Kaneko; Ai Kawana-Tachikawa; Yoko Tajima; Haruo Goto; Dayong Zhu; Kaori Nakayama-Hosoya; Shoichi Iriguchi; Yasushi Uemura; Takafumi Shimizu; Naoya Takayama; Daisuke Yamada; Ken Nishimura; Manami Ohtaka; Nobukazu Watanabe; Satoshi Takahashi; Aikichi Iwamoto; Haruhiko Koseki; Mahito Nakanishi; Koji Eto; Hiromitsu Nakauchi
Journal: Cell Stem Cell Date: 2013-01-03 Impact factor: 24.633

Review 2. Regulatory networks defining EMT during cancer initiation and progression.

Authors: Bram De Craene; Geert Berx
Journal: Nat Rev Cancer Date: 2013-02 Impact factor: 60.716

3. Immunogenicity of induced pluripotent stem cells.

Authors: Tongbiao Zhao; Zhen-Ning Zhang; Zhili Rong; Yang Xu
Journal: Nature Date: 2011-05-13 Impact factor: 49.962

4. Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells.

Authors: Venkata Lokesh Battula; Kurt William Evans; Brett George Hollier; Yuexi Shi; Frank C Marini; Ayyakkannu Ayyanan; Rui-Yu Wang; Cathrin Brisken; Rudy Guerra; Michael Andreeff; Sendurai A Mani
Journal: Stem Cells Date: 2010-08 Impact factor: 6.277

Review 5. Tracing the cellular origin of cancer.

Authors: Cédric Blanpain
Journal: Nat Cell Biol Date: 2013-01-20 Impact factor: 28.824

6. Generation of germline-competent induced pluripotent stem cells.

Authors: Keisuke Okita; Tomoko Ichisaka; Shinya Yamanaka
Journal: Nature Date: 2007-06-06 Impact factor: 49.962

7. Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells.

Authors: Ryoko Araki; Masahiro Uda; Yuko Hoki; Misato Sunayama; Miki Nakamura; Shunsuke Ando; Mayumi Sugiura; Hisashi Ideno; Akemi Shimada; Akira Nifuji; Masumi Abe
Journal: Nature Date: 2013-01-09 Impact factor: 49.962

8. Architecture of the human regulatory network derived from ENCODE data.

Authors: Mark B Gerstein; Anshul Kundaje; Manoj Hariharan; Stephen G Landt; Koon-Kiu Yan; Chao Cheng; Xinmeng Jasmine Mu; Ekta Khurana; Joel Rozowsky; Roger Alexander; Renqiang Min; Pedro Alves; Alexej Abyzov; Nick Addleman; Nitin Bhardwaj; Alan P Boyle; Philip Cayting; Alexandra Charos; David Z Chen; Yong Cheng; Declan Clarke; Catharine Eastman; Ghia Euskirchen; Seth Frietze; Yao Fu; Jason Gertz; Fabian Grubert; Arif Harmanci; Preti Jain; Maya Kasowski; Phil Lacroute; Jing Jane Leng; Jin Lian; Hannah Monahan; Henriette O'Geen; Zhengqing Ouyang; E Christopher Partridge; Dorrelyn Patacsil; Florencia Pauli; Debasish Raha; Lucia Ramirez; Timothy E Reddy; Brian Reed; Minyi Shi; Teri Slifer; Jing Wang; Linfeng Wu; Xinqiong Yang; Kevin Y Yip; Gili Zilberman-Schapira; Serafim Batzoglou; Arend Sidow; Peggy J Farnham; Richard M Myers; Sherman M Weissman; Michael Snyder
Journal: Nature Date: 2012-09-06 Impact factor: 49.962

Perspectives of gene combinations in phenotype presentation.

1. Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.

Review 2. Regulatory networks defining EMT during cancer initiation and progression.

3. Immunogenicity of induced pluripotent stem cells.

4. Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells.

Review 5. Tracing the cellular origin of cancer.

6. Generation of germline-competent induced pluripotent stem cells.

7. Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells.

8. Architecture of the human regulatory network derived from ENCODE data.

9. Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins?

10. Force and scleraxis synergistically promote the commitment of human ES cells derived MSCs to tenocytes.

1. Origin of cells and network information.

2. Regulated genes in mesenchymal stem cells and gastric cancer.