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Literature DB >> 23948891

How it all started: tau and protein phosphatase 2A.

Abstract

This review is dedicated to Inge Grundke-Iqbal who laid the foundations of the tau field, by isolating tau from the Alzheimer's disease (AD) brain, discovering that tau is hyperphosphorylated, and proving a critical role of protein phosphatase 2A (PP2A) and its endogenous inhibitor I2PP2A in this process. This memorial starts with a few personal notes, and then covers how subcellular fractionation helped in isolating tau. We review in detail the role of PP2A and its endogenous inhibitor in tau phosphorylation. We discuss the role that methylation and phosphorylation have in regulating PP2A activity. We add what we have contributed to understanding the role of tau and PP2A in AD using PP2A transgenic and knockout models, and conclude by addressing two underexplored areas in tau research: tau's non-canonical functions and the role distinct tau isoforms have in a physiological context.

Entities: Disease Gene

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Year: 2013 PMID： 23948891 DOI： 10.3233/JAD-130503

Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472

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Cited

10 in total

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Authors: Sean J Miller; Jenna C Glatzer; Yi-Chun Hsieh; Jeffrey D Rothstein
Journal: J Neurogenet Date: 2018-11-06 Impact factor: 1.250

2. Benzene-induced mouse hematotoxicity is regulated by a protein phosphatase 2A complex that stimulates transcription of cytochrome P4502E1.

Authors: Liping Chen; Ping Guo; Haiyan Zhang; Wenxue Li; Chen Gao; Zhenlie Huang; Junling Fan; Yuling Zhang; Xue Li; Xiaoling Liu; Fangping Wang; Shan Wang; Qingye Li; Zhini He; Huiyao Li; Shen Chen; Xiaonen Wu; Lizhu Ye; Qiong Li; Huanwen Tang; Qing Wang; Guanghui Dong; Yongmei Xiao; Wen Chen; Daochuan Li
Journal: J Biol Chem Date: 2018-12-19 Impact factor: 5.157

3. Reply to Salari et al.: Toward understanding the deep mechanisms regarding the biophotons related to human intelligence.

Authors: Jiapei Dai; Zhuo Wang; Zehua Li; Fangyan Xiao
Journal: Proc Natl Acad Sci U S A Date: 2016-09-12 Impact factor: 11.205

4. Decrease in age-related tau hyperphosphorylation and cognitive improvement following vitamin D supplementation are associated with modulation of brain energy metabolism and redox state.

Authors: T L Briones; H Darwish
Journal: Neuroscience Date: 2014-01-08 Impact factor: 3.590

Review 5. Regulation of protein conformation by Pin1 offers novel disease mechanisms and therapeutic approaches in Alzheimer's disease.

Authors: Jane A Driver; Xiao Zhen Zhou; Kun Ping Lu
Journal: Discov Med Date: 2014-02 Impact factor: 2.970

10. Differential Hyperphosphorylation of Tau-S199, -T231 and -S396 in Organotypic Brain Slices of Alzheimer Mice. A Model to Study Early Tau Hyperphosphorylation Using Okadaic Acid.

Authors: Bettina M Foidl; Christian Humpel
Journal: Front Aging Neurosci Date: 2018-04-19 Impact factor: 5.750

10 in total

How it all started: tau and protein phosphatase 2A.

1. Cortical astroglia undergo transcriptomic dysregulation in the G93A SOD1 ALS mouse model.

2. Benzene-induced mouse hematotoxicity is regulated by a protein phosphatase 2A complex that stimulates transcription of cytochrome P4502E1.

3. Reply to Salari et al.: Toward understanding the deep mechanisms regarding the biophotons related to human intelligence.

4. Decrease in age-related tau hyperphosphorylation and cognitive improvement following vitamin D supplementation are associated with modulation of brain energy metabolism and redox state.

Review 5. Regulation of protein conformation by Pin1 offers novel disease mechanisms and therapeutic approaches in Alzheimer's disease.

6. FAM122A, a new endogenous inhibitor of protein phosphatase 2A.

Review 7. δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities.

8. Saliva tau and phospho-tau-181 measured by Lumipulse in patients with Alzheimer's disease.

Review 9. The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer's disease.

10. Differential Hyperphosphorylation of Tau-S199, -T231 and -S396 in Organotypic Brain Slices of Alzheimer Mice. A Model to Study Early Tau Hyperphosphorylation Using Okadaic Acid.