Literature DB >> 23948863

Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds.

Steven H Liang1, Thomas Lee Collier, Benjamin H Rotstein, Rebecca Lewis, Mia Steck, Neil Vasdev.   

Abstract

We have combined the benefits of both microfluidics and flow hydrogenation to provide facile access to previously underutilized reduction and protecting group chemistries for PET imaging applications. The rapid removal of an O-benzyl protecting group to prepare 2-[(18)F]fluoroquinolin-8-ol and the reduction of a nitro group in the synthesis of 4-[(18)F]fluoroaniline were achieved within 3 minutes.

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Year:  2013        PMID： 23948863     DOI： 10.1039/c3cc45166f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

1.  Evaluation of [18F]-ATRi as PET tracer for in vivo imaging of ATR in mouse models of brain cancer.

Authors:  Giuseppe Carlucci; Brandon Carney; Ahmad Sadique; Axel Vansteene; Jun Tang; Thomas Reiner
Journal:  Nucl Med Biol       Date:  2017-01-16       Impact factor: 2.408

2.  Microfluidic continuous-flow radiosynthesis of [18F]FPEB suitable for human PET imaging.

Authors:  Steven H Liang; Daniel L Yokell; Raul N Jackson; Peter A Rice; Ronald Callahan; Keith A Johnson; David Alagille; Gilles Tamagnan; Thomas Lee Collier; Neil Vasdev
Journal:  Medchemcomm       Date:  2014-04-01       Impact factor: 3.597

3.  Optimization of nucleophilic ¹⁸F radiofluorinations using a microfluidic reaction approach.

Authors:  Giancarlo Pascali; Lidia Matesic; Thomas L Collier; Naomi Wyatt; Benjamin H Fraser; Tien Q Pham; Piero A Salvadori; Ivan Greguric
Journal:  Nat Protoc       Date:  2014-07-31       Impact factor: 13.491

4.  Novel Fluorinated 8-Hydroxyquinoline Based Metal Ionophores for Exploring the Metal Hypothesis of Alzheimer's Disease.

Authors:  Steven H Liang; Adam G Southon; Benjamin H Fraser; Anwen M Krause-Heuer; Bo Zhang; Timothy M Shoup; Rebecca Lewis; Irene Volitakis; Yifeng Han; Ivan Greguric; Ashley I Bush; Neil Vasdev
Journal:  ACS Med Chem Lett       Date:  2015-08-10       Impact factor: 4.345

5.  An efficient new method for the synthesis of 3-[18 F]fluoro-4-aminopyridine via Yamada-Curtius rearrangement.

Authors:  Falguni Basuli; Xiang Zhang; Pedro Brugarolas; Daniel S Reich; Rolf E Swenson
Journal:  J Labelled Comp Radiopharm       Date:  2017-11-30       Impact factor: 1.921

6.  PET neuroimaging studies of [(18)F]CABS13 in a double transgenic mouse model of Alzheimer's disease and nonhuman primates.

Authors:  Steven H Liang; Jason P Holland; Nickeisha A Stephenson; Alina Kassenbrock; Benjamin H Rotstein; Cory P Daignault; Rebecca Lewis; Lee Collier; Jacob M Hooker; Neil Vasdev
Journal:  ACS Chem Neurosci       Date:  2015-03-24       Impact factor: 4.418

7.  Total Radiosynthesis: Thinking outside "the box".

Authors:  Steven H Liang; Neil Vasdev
Journal:  Aust J Chem       Date:  2015-08-28       Impact factor: 1.321

Review 8.  18F-labelled intermediates for radiosynthesis by modular build-up reactions: newer developments.

Authors:  Johannes Ermert
Journal:  Biomed Res Int       Date:  2014-06-23       Impact factor: 3.411

Review 9.  Fluorine-18 radiochemistry, labeling strategies and synthetic routes.

Authors:  Orit Jacobson; Dale O Kiesewetter; Xiaoyuan Chen
Journal:  Bioconjug Chem       Date:  2014-12-12       Impact factor: 4.774

10.  Mechanistic Studies and Radiofluorination of Structurally Diverse Pharmaceuticals with Spirocyclic Iodonium(III) Ylides.

Authors:  Benjamin H Rotstein; Lu Wang; Richard Y Liu; Jon Patteson; Eugene E Kwan; Neil Vasdev; Steven H Liang
Journal:  Chem Sci       Date:  2016-03-24       Impact factor: 9.825
  10 in total

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