| Literature DB >> 23948613 |
Chindu Govindaraj1, Karen Scalzo-Inguanti, Mutsa Madondo, Julene Hallo, Katie Flanagan, Michael Quinn, Magdalena Plebanski.
Abstract
Ovarian cancer is a prevalent gynecological malignancy with potent immune-suppression capabilities; regulatory T cells (Tregs) are significant contributors to this immune-suppression. As ovarian cancer patients present with high levels of TNF and Tregs expressing TNFR2 are associated with maximal suppressive capacity, we investigated TNFR2+ Tregs within these patients. Indeed, TNFR2+ Tregs from tumor-associated ascites were the most potent suppressor T cell fraction. They were abundantly present within the ascites and more suppressive than peripheral blood TNFR2+ Tregs in patients. The increased suppressive capacity can be explained by a distinct cell surface expression profile, which includes high levels of CD39, CD73, TGF-β and GARP. Additionally, CD73 expression level on TNFR2+ Tregs was inversely correlated with IFN-γ production by effector T cells. This Treg fraction can be selectively recruited into the ascites from the peripheral blood of patients. Targeting TNFR2+ Tregs may offer new approaches to enhance the poor survival rates of ovarian cancer.Entities:
Keywords: Ascites;; Immune suppression; Ovarian cancer;; Regulatory T cells;; TNF receptor 2;
Mesh：
Substances：
Year: 2013 PMID： 23948613 DOI： 10.1016/j.clim.2013.07.003
Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969