Stéphanie Servagi Vernat1, David Ali2, Marc Puyraveau3, Romain Viard4, Albert Lisbona5, Pascal Fenoglietto6, Ludovic Bedos6, Libor Makovicka7, Philippe Giraud2. 1. Department of Radiation Oncology, Besançon University Hospital, Besançon, France; University of Franche Comté, IRMA/LCPR-AC/CE UMR 6249 CNRS, Montbéliard, France. Electronic address: stephanie.servagi@gmail.com. 2. Paris Descartes University, Department of Radiation Oncology, Georges Pompidou European Hospital, Paris, France. 3. Clinical Methodology Center, Besançon University Hospital, Besançon, France. 4. AQUILAB, Loos les Lille, France. 5. Department of Radiation Oncology, Centre René Gauducheau, Saint-Herblain, France. 6. Department of Radiation Oncology, Cancer Center Val D'Aurelle, Montpellier, France. 7. University of Franche Comté, IRMA/LCPR-AC/CE UMR 6249 CNRS, Montbéliard, France.
Abstract
BACKGROUND: Intensity Modulated Arc Therapy (IMAT) can be planned and delivered via several techniques. Advanced Radiotherapy (ARTORL) is a prospective study that aims to evaluate the treatment costs and clinical aspects of implementing these IMAT techniques for head and neck cancers. In this context, we evaluated the potential dosimetric gain of Helical Tomotherapy (TomoTherapy, Accuray, HT) versus VMAT (Rapid'Arc(®), Varian Medical System, RA) for oropharyngeal cancer (OC). MATERIAL AND METHODS: Thirty patients were selected from our database in whom bilateral neck irradiation and treatment to the primary were indicated. Each patient was planned twice using both HT and RA planning systems using a simultaneous integrated boost approach. For the planning target volumes (PTV) and organs at risk, ICRU 83 reporting guidelines were followed. RA and HT plans were compared using paired Student's t-test. RESULTS: RA and HT produced plans with a good coverage of PTVs and acceptable sparing of OARs. Although some dosimetric differences were statistically significant, they remained small. However, the near maximal dose to the PRV of spinal cord and brain stem was lower with HT. Regarding normal tissue, HT increased the volume irradiated at doses between 4 and 20 Gy compared to RA. CONCLUSION: In OC, HT and RA showed similar dosimetric results. They represent the maximum gains obtained with photon beams. The medicoeconomic evaluation of our study is ongoing and may reveal differences between these techniques in terms of MU number, fraction time, and clinical evaluation.
BACKGROUND: Intensity Modulated Arc Therapy (IMAT) can be planned and delivered via several techniques. Advanced Radiotherapy (ARTORL) is a prospective study that aims to evaluate the treatment costs and clinical aspects of implementing these IMAT techniques for head and neck cancers. In this context, we evaluated the potential dosimetric gain of Helical Tomotherapy (TomoTherapy, Accuray, HT) versus VMAT (Rapid'Arc(®), Varian Medical System, RA) for oropharyngeal cancer (OC). MATERIAL AND METHODS: Thirty patients were selected from our database in whom bilateral neck irradiation and treatment to the primary were indicated. Each patient was planned twice using both HT and RA planning systems using a simultaneous integrated boost approach. For the planning target volumes (PTV) and organs at risk, ICRU 83 reporting guidelines were followed. RA and HT plans were compared using paired Student's t-test. RESULTS:RA and HT produced plans with a good coverage of PTVs and acceptable sparing of OARs. Although some dosimetric differences were statistically significant, they remained small. However, the near maximal dose to the PRV of spinal cord and brain stem was lower with HT. Regarding normal tissue, HT increased the volume irradiated at doses between 4 and 20 Gy compared to RA. CONCLUSION: In OC, HT and RA showed similar dosimetric results. They represent the maximum gains obtained with photon beams. The medicoeconomic evaluation of our study is ongoing and may reveal differences between these techniques in terms of MU number, fraction time, and clinical evaluation.
Authors: Jonathan Khalifa; Laure Vieillevigne; Sabrina Boyrie; Monia Ouali; Thomas Filleron; Michel Rives; Anne Laprie Journal: Radiat Oncol Date: 2014-11-26 Impact factor: 3.481
Authors: Steffi U Pigorsch; Severin Kampfer; Markus Oechsner; Michael C Mayinger; Petra Mozes; Michal Devecka; Kerstin K Kessel; Stephanie E Combs; Jan J Wilkens Journal: Radiat Oncol Date: 2020-11-02 Impact factor: 3.481