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Literature DB >> 23947891

Anthrax toxin-induced rupture of artificial lipid bilayer membranes.

Brian J Nablo¹, Rekha G Panchal, Sina Bavari, Tam L Nguyen, Rick Gussio, Wil Ribot, Art Friedlander, Donald Chabot, Joseph E Reiner, Joseph W F Robertson, Arvind Balijepalli, Kelly M Halverson, John J Kasianowicz.

Abstract

We demonstrate experimentally that anthrax toxin complexes rupture artificial lipid bilayer membranes when isolated from the blood of infected animals. When the solution pH is temporally acidified to mimic that process in endosomes, recombinant anthrax toxin forms an irreversibly bound complex, which also destabilizes membranes. The results suggest an alternative mechanism for the translocation of anthrax toxin into the cytoplasm.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2013 PMID： 23947891 PMCID： PMC3751978 DOI： 10.1063/1.4816467

Source DB: PubMed Journal: J Chem Phys ISSN： 0021-9606 Impact factor: 3.488

116 in total

1. Crystal structure of the anthrax lethal factor.

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Authors: Francisco J Maldonado-Arocho; Jennifer A Fulcher; Benhur Lee; Kenneth A Bradley
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Authors: W L Shoop; Y Xiong; J Wiltsie; A Woods; J Guo; J V Pivnichny; T Felcetto; B F Michael; A Bansal; R T Cummings; B R Cunningham; A M Friedlander; C M Douglas; S B Patel; D Wisniewski; G Scapin; S P Salowe; D M Zaller; K T Chapman; E M Scolnick; D M Schmatz; K Bartizal; M MacCoss; J D Hermes
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Authors: D Morikis; A H Elcock; P A Jennings; J A McCammon
Journal: Protein Sci Date: 2001-11 Impact factor: 6.725

10. Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process.

Authors: A M Friedlander
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10 in total

1. Effect of late endosomal DOBMP lipid and traditional model lipids of electrophysiology on the anthrax toxin channel activity.

Authors: Nnanya Kalu; Yoav Atsmon-Raz; Sanaz Momben Abolfath; Laura Lucas; Clare Kenney; Stephen H Leppla; D Peter Tieleman; Ekaterina M Nestorovich
Journal: Biochim Biophys Acta Biomembr Date: 2018-08-23 Impact factor: 3.747

Review 2. Multivalent Inhibitors of Channel-Forming Bacterial Toxins.

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Journal: Curr Top Microbiol Immunol Date: 2017 Impact factor: 4.291

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Authors: Ekaterina M Nestorovich; Sergey M Bezrukov
Journal: Expert Opin Drug Discov Date: 2014-01-22 Impact factor: 6.098

4. Effect of endosomal acidification on small ion transport through the anthrax toxin PA₆₃ channel.

Authors: Nnanya Kalu; Antonio Alcaraz; Goli Yamini; Sanaz Momben Abolfath; Laura Lucas; Clare Kenney; Vicente M Aguilella; Ekaterina M Nestorovich
Journal: FEBS Lett Date: 2017-10-19 Impact factor: 4.124

5. Placement of oppositely charged aminoacids at a polypeptide termini determines the voltage-controlled braking of polymer transport through nanometer-scale pores.

Authors: Alina Asandei; Mauro Chinappi; Jong-Kook Lee; Chang Ho Seo; Loredana Mereuta; Yoonkyung Park; Tudor Luchian
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10. Solution Structures of Bacillus anthracis Protective Antigen Proteins Using Small Angle Neutron Scattering and Protective Antigen 63 Ion Channel Formation Kinetics.

Authors: Ariel Michelman-Ribeiro; Kenneth A Rubinson; Vitalii Silin; John J Kasianowicz
Journal: Toxins (Basel) Date: 2021-12-11 Impact factor: 4.546