Literature DB >> 23947569

Enantioselective intermolecular formal [3 + 3] cycloaddition of 2,3-disubstituted indoles with acrolein.

Jianbiao Huang1, Long Zhao, Yong Liu, Weiguo Cao, Xiaoyu Wu.   

Abstract

An expedient enantioselective synthesis of highly substituted hydrocarbazoles has been realized by an organocatalyzed formal [3 + 3] cycloaddition between acrolein and 2,3-disubstituted indoles. Tricyclic hydrocarbazoles were obtained from a broad range of 2,3-disubstituted indoles and acrolein in good to excellent yields and excellent enantioselectivites.

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Year:  2013        PMID: 23947569     DOI: 10.1021/ol401809d

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

1.  The [3 + 3]-cycloaddition alternative for heterocycle syntheses: catalytically generated metalloenolcarbenes as dipolar adducts.

Authors:  Xinfang Xu; Michael P Doyle
Journal:  Acc Chem Res       Date:  2014-03-20       Impact factor: 22.384

  1 in total

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