Literature DB >> 23946313

Benefits of putaminal GDNF infusion in Parkinson disease are maintained after GDNF cessation.

Nikunj K Patel1, Nicola Pavese, Shazia Javed, Gary R Hotton, David J Brooks, Steven S Gill.   

Abstract

We previously reported clinical improvement, increase in putamen [(18)F]-dopa uptake on PET imaging, and neuropathologic evidence of sprouting of dopaminergic fibers following chronic intraputaminal delivery of glial cell line-derived neurotrophic factor (GDNF) in idiopathic Parkinson disease (PD).(1-3) We now provide clinical and PET evidence of persistent efficacy lasting for at least 3 years following cessation of GDNF infusion in a patient with PD. This is a single-case observational study, providing Class IV evidence.

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Year:  2013        PMID： 23946313      PMCID： PMC3795600          DOI： 10.1212/WNL.0b013e3182a55ea5

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  6 in total

1.  Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study.

Authors:  Nikunj K Patel; Martin Bunnage; Puneet Plaha; Clive N Svendsen; Peter Heywood; Steven S Gill
Journal:  Ann Neurol       Date:  2005-02       Impact factor: 10.422

2.  Core assessment program for intracerebral transplantations (CAPIT).

Authors:  J W Langston; H Widner; C G Goetz; D Brooks; S Fahn; T Freeman; R Watts
Journal:  Mov Disord       Date:  1992       Impact factor: 10.338

3.  Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal.

Authors:  John T Slevin; Don M Gash; Charles D Smith; Greg A Gerhardt; Richard Kryscio; Himachandra Chebrolu; Ashley Walton; Renee Wagner; A Byron Young
Journal:  J Neurosurg       Date:  2007-04       Impact factor: 5.115

4.  Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease.

Authors:  Steven S Gill; Nikunj K Patel; Gary R Hotton; Karen O'Sullivan; Renée McCarter; Martin Bunnage; David J Brooks; Clive N Svendsen; Peter Heywood
Journal:  Nat Med       Date:  2003-03-31       Impact factor: 53.440

5.  Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease.

Authors:  Anthony E Lang; Steven Gill; Nik K Patel; Andres Lozano; John G Nutt; Richard Penn; David J Brooks; Gary Hotton; Elena Moro; Peter Heywood; Matthew A Brodsky; Kim Burchiel; Patrick Kelly; Arif Dalvi; Burton Scott; Mark Stacy; Dennis Turner; V G Frederich Wooten; William J Elias; Edward R Laws; Vijay Dhawan; A Jon Stoessl; James Matcham; Robert J Coffey; Michael Traub
Journal:  Ann Neurol       Date:  2006-03       Impact factor: 10.422

6.  Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain.

Authors:  Seth Love; Puneet Plaha; Nikunj K Patel; Gary R Hotton; David J Brooks; Steven S Gill
Journal:  Nat Med       Date:  2005-07       Impact factor: 53.440
  6 in total
  15 in total

1.  Can Parkinson's disease be cured by stimulating neurogenesis?

Authors:  Thomas Foltynie
Journal:  J Clin Invest       Date:  2015-02-17       Impact factor: 14.808

2.  IGF-1 protects dopamine neurons against oxidative stress: association with changes in phosphokinases.

Authors:  Amina El Ayadi; Michael J Zigmond; Amanda D Smith
Journal:  Exp Brain Res       Date:  2016-02-19       Impact factor: 1.972

Review 3.  Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy.

Authors:  Tuane Bazanella Sampaio; Anne Suely Savall; Maria Eduarda Ziani Gutierrez; Simone Pinton
Journal:  Neural Regen Res       Date:  2017-04       Impact factor: 5.135

4.  Ultrasound-Triggered Effects of the Microbubbles Coupled to GDNF Plasmid-Loaded PEGylated Liposomes in a Rat Model of Parkinson's Disease.

Authors:  Peijian Yue; Wang Miao; Lin Gao; Xinyu Zhao; Junfang Teng
Journal:  Front Neurosci       Date:  2018-04-06       Impact factor: 4.677

5.  Inducible Expression of GDNF in Transplanted iPSC-Derived Neural Progenitor Cells.

Authors:  Aslam Abbasi Akhtar; Genevieve Gowing; Naomi Kobritz; Steve E Savinoff; Leslie Garcia; David Saxon; Noell Cho; Gibum Kim; Colton M Tom; Hannah Park; George Lawless; Brandon C Shelley; Virginia B Mattis; Joshua J Breunig; Clive N Svendsen
Journal:  Stem Cell Reports       Date:  2018-04-26       Impact factor: 7.765

Review 6.  Restorative Strategies in Movement Disorders: the Contribution of Imaging.

Authors:  Nicholas P Lao-Kaim; Paola Piccini; Yen F Tai
Journal:  Curr Neurol Neurosci Rep       Date:  2017-11-02       Impact factor: 5.081

7.  Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson's disease.

Authors:  Alan Whone; Matthias Luz; Mihaela Boca; Max Woolley; Lucy Mooney; Sonali Dharia; Jack Broadfoot; David Cronin; Christian Schroers; Neil U Barua; Lara Longpre; C Lynn Barclay; Chris Boiko; Greg A Johnson; H Christian Fibiger; Rob Harrison; Owen Lewis; Gemma Pritchard; Mike Howell; Charlie Irving; David Johnson; Suk Kinch; Christopher Marshall; Andrew D Lawrence; Stephan Blinder; Vesna Sossi; A Jon Stoessl; Paul Skinner; Erich Mohr; Steven S Gill
Journal:  Brain       Date:  2019-03-01       Impact factor: 13.501

8.  CDNF Protein Therapy in Parkinson's Disease.

Authors:  Henri J Huttunen; Mart Saarma
Journal:  Cell Transplant       Date:  2019-04-04       Impact factor: 4.064

9.  Are Temporal Differences in GDNF and NOS Isoform Induction Contributors to Neurodegeneration? A Fluorescence Microscopy-Based Study.

Authors:  Marie-Francoise Doursout; Yangyan Liang; Mya C Schiess; Angelica Padilla; Brian J Poindexter; Diane L M Hickson-Bick; Roger J Bick
Journal:  Open Neurol J       Date:  2016-08-26

Review 10.  Is insulin-like growth factor-1 involved in Parkinson's disease development?

Authors:  Inma Castilla-Cortázar; Gabriel A Aguirre; Giovana Femat-Roldán; Irene Martín-Estal; Luis Espinosa
Journal:  J Transl Med       Date:  2020-02-11       Impact factor: 5.531
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