| Literature DB >> 23943005 |
Shishir Srivastava1, Ravi Sonkar, Sunil Kumar Mishra, Avinash Tiwari, Vishal M Balaramnavar, Vishal Balramnavar, Snober Mir, Gitika Bhatia, Anil K Saxena, Vijai Lakshmi.
Abstract
A series of Lupeol-based chalcones have been synthesized aiming to enhance the therapeutic efficacy of parent compound, the novel compounds were evaluated for their antidyslipidemic activity in triton-WR 1339 induced hyperlipidemic rats. Among the ten synthesized chalcones, the most active K4, K8, and K9 reversed the plasma levels of TC by (24, 25, 27 %), phospholipid by (25, 26, 25 %) and triacylglycerol by (27, 24, 24 %) respectively. In addition, the compounds showed significant in vitro antioxidant activity. The lipid lowering activity of these compounds were mediated through lipoprotein lipase activation (12-21 %) and enhanced post-heparin lipolytic activity (15-16 %). The compounds also displayed noteworthy inhibitory effect on 3-hydroxy-3-methyl-glutaryl reductase activity (in vitro). The in vitro effect of the most active compounds on MDI-induced adipogenesis using 3T3-L1 preadipocytes at 10 and 20 μM concentrations showed significant inhibition (20-32 %) of adipogenesis.Entities:
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Year: 2013 PMID： 23943005 DOI： 10.1007/s11745-013-3824-0
Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880