Literature DB >> 23942893

Stabilizing effect of electrostatic vs. aromatic interactions in diproline nucleated peptide β-hairpins.

Kamlesh Madhusudan Makwana1, Srinivasarao Raghothama, Radhakrishnan Mahalakshmi.   

Abstract

The contribution of Tyr-His vs. Cys-His interacting pairs to the scaffold stability of (D)Pro-(L)Pro nucleated peptide β-hairpins has been examined. We present direct evidence for the superiority of the Cys-His pairs, mediated by sulphur-imidazole interactions, as added stabilizing agents of the β-hairpin scaffold.

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Year:  2013        PMID： 23942893     DOI： 10.1039/c3cp52770k

Source DB:  PubMed          Journal:  Phys Chem Chem Phys        ISSN： 1463-9076            Impact factor:   3.676


  3 in total

Review 1.  Implications of aromatic-aromatic interactions: From protein structures to peptide models.

Authors:  Kamlesh Madhusudan Makwana; Radhakrishnan Mahalakshmi
Journal:  Protein Sci       Date:  2015-10-07       Impact factor: 6.725

2.  N-helix and Cysteines Inter-regulate Human Mitochondrial VDAC-2 Function and Biochemistry.

Authors:  Svetlana Rajkumar Maurya; Radhakrishnan Mahalakshmi
Journal:  J Biol Chem       Date:  2015-10-20       Impact factor: 5.157

3.  Salvaging the Thermodynamic Destabilization of Interface Histidine in Transmembrane β-Barrels.

Authors:  Bharat Ramasubramanian Iyer; Pallavi Vijay Vetal; Henna Noordeen; Punit Zadafiya; Radhakrishnan Mahalakshmi
Journal:  Biochemistry       Date:  2018-10-16       Impact factor: 3.162
  3 in total

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