Literature DB >> 23941043

Sesterterpenoids isolated from a northeastern Pacific Phorbas sp.

Julie Daoust1, Min Chen, Meng Wang, David E Williams, Miguel Angel Garcia Chavez, Yan Alexander Wang, Catherine E Merchant, Angelo Fontana, Timothy J Kieffer, Raymond J Andersen.   

Abstract

Four new sesterterpenoids, ansellone B (4), phorbadione (5), secoepoxyansellone A (6), and alotaketal C (7), have been isolated from specimens of the sponge Phorbas sp. collected in British Columbia. Ansellone B (4) has an unprecedented heterocyclic skeleton featuring an oxocane ring, and secoepoxyansellone A (6) is the first example of the degraded "secoansellane" sesterterpenoid carbon skeleton. Alotaketal C (7) is an activator of cAMP signaling in HEK cells.

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Year:  2013        PMID： 23941043     DOI： 10.1021/jo4014589

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  7 in total

Review 1.  Biologically active marine natural products and their molecular targets discovered using a chemical genetics approach.

Authors:  David E Williams; Raymond J Andersen
Journal:  Nat Prod Rep       Date:  2019-11-21       Impact factor: 13.423

Review 2.  Marine Pharmacology in 2012-2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Orazio Taglialatela-Scafati; Nobuhiro Fusetani
Journal:  Mar Drugs       Date:  2017-08-29       Impact factor: 5.118

3.  Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products.

Authors:  Khumoekae Richard; David E Williams; E Dilip de Silva; Mark A Brockman; Zabrina L Brumme; Raymond J Andersen; Ian Tietjen
Journal:  Viruses       Date:  2018-06-27       Impact factor: 5.048

4.  Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells.

Authors:  Hyun Bong Park; Nguyen Quoc Tuan; Joonseok Oh; Younglim Son; Mark T Hamann; Robert Stone; Michelle Kelly; Sangtaek Oh; MinKyun Na
Journal:  Mar Drugs       Date:  2018-08-27       Impact factor: 5.118

Review 5.  A Soft Spot for Chemistry-Current Taxonomic and Evolutionary Implications of Sponge Secondary Metabolite Distribution.

Authors:  Adrian Galitz; Yoichi Nakao; Peter J Schupp; Gert Wörheide; Dirk Erpenbeck
Journal:  Mar Drugs       Date:  2021-08-04       Impact factor: 5.118

Review 6.  Bioactive natural products from marine sponges belonging to family Hymedesmiidae.

Authors:  Asmaa Abo Elgoud Said; Basma Khalaf Mahmoud; Eman Zekry Attia; Usama Ramadan Abdelmohsen; Mostafa Ahmed Fouad
Journal:  RSC Adv       Date:  2021-04-30       Impact factor: 3.361

Review 7.  Exploring Chemical Diversity of Phorbas Sponges as a Source of Novel Lead Compounds in Drug Discovery.

Authors:  Alessia Caso; Fernanda Barbosa da Silva; Germana Esposito; Roberta Teta; Gerardo Della Sala; Laura P A Nunes Cavalcanti; Alessandra Leda Valverde; Roberto Carlos C Martins; Valeria Costantino
Journal:  Mar Drugs       Date:  2021-11-26       Impact factor: 5.118
  7 in total

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