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Literature DB >> 23939893

Microcalorimetry assay for rapid detection of voriconazole resistance in Aspergillus fumigatus.

Ulrika Furustrand Tafin¹, Jacques F Meis, Andrej Trampuz.

Abstract

We describe a calorimetric assay for detection of voriconazole-resistant Aspergillus fumigatus within 8 h. Among 27 genetically distinct strains, all 21 resistant and all 6 susceptible strains were correctly identified by measurement of fungal heat production in the presence of voriconazole. This proof-of-concept study demonstrates the potential of microcalorimetry for rapid detection of azole resistance in A. fumigatus.

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Year: 2013 PMID： 23939893 PMCID： PMC3811254 DOI： 10.1128/AAC.01379-13

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

21 in total

1. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America.

Authors: Thomas J Walsh; Elias J Anaissie; David W Denning; Raoul Herbrecht; Dimitrios P Kontoyiannis; Kieren A Marr; Vicki A Morrison; Brahm H Segal; William J Steinbach; David A Stevens; Jo-Anne van Burik; John R Wingard; Thomas F Patterson
Journal: Clin Infect Dis Date: 2008-02-01 Impact factor: 9.079

2. Performance of microcalorimetry for early detection of methicillin resistance in clinical isolates of Staphylococcus aureus.

Authors: Daniela Baldoni; Heinz Hermann; Reno Frei; Andrej Trampuz; Andrea Steinhuber
Journal: J Clin Microbiol Date: 2009-01-21 Impact factor: 5.948

3. EUCAST Technical Note on the method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for conidia-forming moulds.

Authors:
Journal: Clin Microbiol Infect Date: 2008-10 Impact factor: 8.067

Review 4. Azole resistance in Aspergillus fumigatus: a new challenge in the management of invasive aspergillosis?

Authors: Eveline Snelders; Willem J G Melchers; Paul E Verweij
Journal: Future Microbiol Date: 2011-03 Impact factor: 3.165

5. Impact of cyp51A mutations on the pharmacokinetic and pharmacodynamic properties of voriconazole in a murine model of disseminated aspergillosis.

Authors: Eleftheria Mavridou; Roger J M Bruggemann; Willem J G Melchers; Paul E Verweij; Johan W Mouton
Journal: Antimicrob Agents Chemother Date: 2010-08-23 Impact factor: 5.191

6. High prevalence of azole-resistant Aspergillus fumigatus in adults with cystic fibrosis exposed to itraconazole.

Authors: Pierre-Régis Burgel; Marie-Thérèse Baixench; Michaël Amsellem; Etienne Audureau; Jeanne Chapron; Reem Kanaan; Isabelle Honoré; Jean Dupouy-Camet; Daniel Dusser; Corné H Klaassen; Jacques F Meis; Dominique Hubert; André Paugam
Journal: Antimicrob Agents Chemother Date: 2011-11-28 Impact factor: 5.191

7. Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India.

Authors: Anuradha Chowdhary; Shallu Kathuria; Harbans S Randhawa; Shailendra N Gaur; Corné H Klaassen; Jacques F Meis
Journal: J Antimicrob Chemother Date: 2011-10-25 Impact factor: 5.790

8. Novel mixed-format real-time PCR assay to detect mutations conferring resistance to triazoles in Aspergillus fumigatus and prevalence of multi-triazole resistance among clinical isolates in the Netherlands.

Authors: Corné H W Klaassen; Hanneke A de Valk; Ilse M Curfs-Breuker; Jacques F Meis
Journal: J Antimicrob Chemother Date: 2010-02-18 Impact factor: 5.790