| Literature DB >> 23939892 |
Dae Hun Kim1, Ji-Young Choi, Hae Won Kim, So Hyun Kim, Doo Ryeon Chung, Kyong Ran Peck, Visanu Thamlikitkul, Thomas Man-Kit So, Rohani M D Yasin, Po-Ren Hsueh, Celia C Carlos, Li Yang Hsu, Latre Buntaran, M K Lalitha, Jae-Hoon Song, Kwan Soo Ko.
Abstract
In this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaR-type resistance islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone 2 (GC2), was the most prevalent in most Asian locales (83/108 isolates; 76.9%). CC108, or GC1, was a predominant clone in India. OXA-23 oxacillinase was detected in CRAB isolates from most Asian locales except Taiwan. blaOXA-24 was found in CRAB isolates from Taiwan. AbaR4-type resistance islands, which were divided into six subtypes, were identified in most CRAB isolates investigated. Five isolates from India, Malaysia, Singapore, and Hong Kong contained AbaR3-type resistance islands. Of these, three isolates harbored both AbaR3- and AbaR4-type resistance islands simultaneously. In this study, GC2 was revealed as a prevalent clone in most Asian locales, with the AbaR4-type resistance island predominant, with diverse variants. The significance of this study lies in identifying the spread of global clones of carbapenem-resistant A. baumannii in Asia.Entities:
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Year: 2013 PMID： 23939892 PMCID： PMC3811275 DOI： 10.1128/AAC.00633-13
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191