| Literature DB >> 23939796 |
You-Heng Gao1, Zhi-Xiong Wei, Yi Cheng, Teng-Hua Wang, Lin Ni, Xiao-Hong Zhou, Li-Yuan Zhang.
Abstract
Four new ent-kaurane diterpenoids, rabdonervosins G-J (1-4, resp.), were isolated from the leaves and stems of Isodon nervosus. Their structures were elucidated by extensive spectroscopic analyses, including 1D-, 2D-NMR and HR mass spectra. Compound 2 showed potent cytotoxicity against the HepG2 and PC-9/ZD cell lines with IC50 values of 2.36 and 6.07 μM, respectively, and compound 3 exhibited cytotoxicity against the HepG2 and CNE2 cell lines with IC50 values of 8.64 and 9.77 μM, respectively.Entities:
Keywords: Cytotoxic activity; Isodon nervosus; Rabdonervosins G - J; Terpenoids; ent-Kaurane diterpenoids
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Year: 2013 PMID： 23939796 DOI： 10.1002/cbdv.201200201
Source DB: PubMed Journal: Chem Biodivers ISSN： 1612-1872 Impact factor: 2.408