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Literature DB >> 23939727

Comparative metabolomic analysis of an alternative biosynthetic pathway to pseudosugars in Actinosynnema mirum DSM 43827.

Shumpei Asamizu¹, Mostafa Abugreen, Taifo Mahmud.

Abstract

Entities: Chemical Disease Species

Keywords: Actinosynnema mirum; metabolism; natural products; pseudoglycosyltransferase; pseudosugar; validoxylamine A

Mesh：

Substances：

Year: 2013 PMID： 23939727 PMCID： PMC3835175 DOI： 10.1002/cbic.201300384

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

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16 in total

1. The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase.

Authors: Chang-Sheng Zhang; Michael Podeschwa; Hans-Josef Altenbach; Wolfgang Piepersberg; Udo F Wehmeier
Journal: FEBS Lett Date: 2003-04-10 Impact factor: 4.124

2. Evolutionary divergence of sedoheptulose 7-phosphate cyclases leads to several distinct cyclic products.

Authors: Shumpei Asamizu; Pengfei Xie; Corey J Brumsted; Patricia M Flatt; Taifo Mahmud
Journal: J Am Chem Soc Date: 2012-07-05 Impact factor: 15.419

3. Characterization and functional modification of StaC and RebC, which are involved in the pyrrole oxidation of indolocarbazole biosynthesis.

Authors: Shumpei Asamizu; Yoshitsugu Shiro; Yasuhiro Igarashi; Shingo Nagano; Hiroyasu Onaka
Journal: Biosci Biotechnol Biochem Date: 2011-11-07 Impact factor: 2.043

4. Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.

Authors: Shumpei Asamizu; Jongtae Yang; Khaled H Almabruk; Taifo Mahmud
Journal: J Am Chem Soc Date: 2011-07-18 Impact factor: 15.419

5. Actinosynnema mirum, a new producer of nocardicin antibiotics.

Authors: K Watanabe; T Okuda; K Yokose; T Furumai; H B Maruyama
Journal: J Antibiot (Tokyo) Date: 1983-03 Impact factor: 2.649

6. ValC, a new type of C7-Cyclitol kinase involved in the biosynthesis of the antifungal agent validamycin A.

Authors: Kazuyuki Minagawa; Yirong Zhang; Takuya Ito; Linquan Bai; Zixin Deng; Taifo Mahmud
Journal: Chembiochem Date: 2007-04-16 Impact factor: 3.164

7. Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.

Authors: Chang-Sheng Zhang; Ansgar Stratmann; Oliver Block; Ralph Brückner; Michael Podeschwa; Hans-Josef Altenbach; Udo F Wehmeier; Wolfgang Piepersberg
Journal: J Biol Chem Date: 2002-04-05 Impact factor: 5.157

8. Microbial degradation of validamycin A by Flavobacterium saccharophilum. Enzymatic cleavage of C-N linkage in validoxylamine A.

Authors: N Asano; M Takeuchi; K Ninomiya; Y Kameda; K Matsui
Journal: J Antibiot (Tokyo) Date: 1984-08 Impact factor: 2.649

9. Studies on validamycins, new antibiotics. VI. Validamine, hydroxyvalidamine and validatol, new cyclitols.

Authors: S Horii; T Iwasa; E Mizuta; Y Kameda
Journal: J Antibiot (Tokyo) Date: 1971-01 Impact factor: 2.649

10. antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences.

Authors: Marnix H Medema; Kai Blin; Peter Cimermancic; Victor de Jager; Piotr Zakrzewski; Michael A Fischbach; Tilmann Weber; Eriko Takano; Rainer Breitling
Journal: Nucleic Acids Res Date: 2011-06-14 Impact factor: 16.971

5 in total

Comparative metabolomic analysis of an alternative biosynthetic pathway to pseudosugars in Actinosynnema mirum DSM 43827.

1. The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase.

2. Evolutionary divergence of sedoheptulose 7-phosphate cyclases leads to several distinct cyclic products.

3. Characterization and functional modification of StaC and RebC, which are involved in the pyrrole oxidation of indolocarbazole biosynthesis.

4. Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.

5. Actinosynnema mirum, a new producer of nocardicin antibiotics.

6. ValC, a new type of C7-Cyclitol kinase involved in the biosynthesis of the antifungal agent validamycin A.

7. Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.

8. Microbial degradation of validamycin A by Flavobacterium saccharophilum. Enzymatic cleavage of C-N linkage in validoxylamine A.

9. Studies on validamycins, new antibiotics. VI. Validamine, hydroxyvalidamine and validatol, new cyclitols.

10. antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences.

Review 1. The sedoheptulose 7-phosphate cyclases and their emerging roles in biology and ecology.

2. Distinct Substrate Specificity and Catalytic Activity of the Pseudoglycosyltransferase VldE.

3. Evolution and Distribution of C₇-Cyclitol Synthases in Prokaryotes and Eukaryotes.

4. Improved l-phenylglycine synthesis by introducing an engineered cofactor self-sufficient system.

5. p-Aminophenylalanine Involved in the Biosynthesis of Antitumor Dnacin B1 for Quinone Moiety Formation.