| Literature DB >> 23939469 |
Yi Feng1, Xitong Zhao, Chunfen Zhou, Lu Yang, Yingwei Liu, Ce Bian, Jinhai Gou, Xiaojuan Lin, Zhenling Wang, Xia Zhao.
Abstract
The Val158Met polymorphism of the COMT gene has been implicated in susceptibility to uterine leiomyoma (ULM), but the reported results were inconclusive. The aim of the study was to evaluate the Val158Met polymorphism of the COMT gene and the risk of ULM by meta-analysis. A comprehensive electronic search for relevant articles was conducted in Pubmed, Embase, CNKI, Wanfang, and Weipu databases. Statistical analysis was performed by using the Revman4.2 software and Stata10.0 software. A total of 7 articles including 12 case-control studies were identified in this meta-analysis. The results showed that the polymorphism was associated with decreased risk of ULM (Met/Met+Val/Met vs. Met/Met: OR=0.84, 95% CI=0.70-0.99, Z=2.07, p=0.04). In the subgroup analyses by ethnicity, significant decreased risk was found among the black populations (OR=0.68, 95% CI=0.48-0.97, Z=2.15, p=0.03). The current meta-analysis suggested that the Val158Met polymorphism in the COMT gene was associated with decreased risk of ULM, especially in the black population. Future studies are needed to validate our conclusions.Entities:
Keywords: CI; COMT; COMT gene; Catechol-O-methyltransferase; F; GWA; I; I statistic for heterogeneity; Meta-analysis; OR; Phet; Polymorphism; ULM; Uterine leiomyoma; Z; Z value for Q statistic; catechol-O-methyltransferase gene; confidence interval; fixed model; genome-wide association; odds ratio; p; p value for heterogeneity; p-value for Q statistic; uterine leiomyoma
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Year: 2013 PMID： 23939469 DOI： 10.1016/j.gene.2013.07.019
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688