Literature DB >> 23939425

Probing the reactivity of o-phthalaldehydic acid/methyl ester: synthesis of N-isoindolinones and 3-arylaminophthalides.

Sreeman K Mamidyala1, Matthew A Cooper.   

Abstract

A new method for the synthesis of N-substituted isoindolinones and 3-arylaminophthalides was developed through aza-Wittig/cyclisation. The reaction of o-phthalaldehydic acid methyl ester with benzylic, aromatic and aliphatic azides gave N-isoindolinones whereas reaction of o-phthalaldehydic acid with the aromatic azides gave 3-arylaminophthalides.

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Year:  2013        PMID： 23939425     DOI： 10.1039/c3cc43838d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity.

Authors:  Akihiro Sugawara; Hitomi Maruyama; Sho Shibusawa; Hidehito Matsui; Tomoyasu Hirose; Ayumi Tsutsui; Robrecht Froyman; Carolin Ludwig; Johannes Koebberling; Hideaki Hanaki; Gerd Kleefeld; Satoshi Ōmura; Toshiaki Sunazuka
Journal:  J Antibiot (Tokyo)       Date:  2017-05-31       Impact factor: 2.649

2.  Synthetic Studies of the Rubellin Natural Products: Development of a Stereoselective Strategy and Total Synthesis of (+)-Rubellin C.

Authors:  Jackson A Gartman; Uttam K Tambar
Journal:  J Org Chem       Date:  2021-07-21       Impact factor: 4.198

3.  Unprecedented selective homogeneous cobalt-catalysed reductive alkoxylation of cyclic imides under mild conditions.

Authors:  Jose R Cabrero-Antonino; Rosa Adam; Veronica Papa; Mattes Holsten; Kathrin Junge; Matthias Beller
Journal:  Chem Sci       Date:  2017-06-12       Impact factor: 9.825
  3 in total

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