Literature DB >> 23938363

Omics technologies and the study of human ageing.

Ana M Valdes1, Daniel Glass, Tim D Spector.   

Abstract

Normal ageing is associated with diverse physiological changes in all organ systems but the rate and extent of these changes vary markedly among individuals. One aspect of ageing research focuses on the molecular profiling of the changes that occur with increasing age in humans. Such profiling has implications for disease prevention and treatment. New high-throughput 'omics' technologies (such as genomics, metabolomics, metagenomics and transcriptomics) are enabling detailed studies of these molecular changes and are thus revealing information about the biological pathways that change with age.

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Year:  2013        PMID： 23938363     DOI： 10.1038/nrg3553

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN： 1471-0056            Impact factor:   53.242


  47 in total

1.  Enterotypes of the human gut microbiome.

Authors:  Manimozhiyan Arumugam; Jeroen Raes; Eric Pelletier; Denis Le Paslier; Takuji Yamada; Daniel R Mende; Gabriel R Fernandes; Julien Tap; Thomas Bruls; Jean-Michel Batto; Marcelo Bertalan; Natalia Borruel; Francesc Casellas; Leyden Fernandez; Laurent Gautier; Torben Hansen; Masahira Hattori; Tetsuya Hayashi; Michiel Kleerebezem; Ken Kurokawa; Marion Leclerc; Florence Levenez; Chaysavanh Manichanh; H Bjørn Nielsen; Trine Nielsen; Nicolas Pons; Julie Poulain; Junjie Qin; Thomas Sicheritz-Ponten; Sebastian Tims; David Torrents; Edgardo Ugarte; Erwin G Zoetendal; Jun Wang; Francisco Guarner; Oluf Pedersen; Willem M de Vos; Søren Brunak; Joel Doré; María Antolín; François Artiguenave; Hervé M Blottiere; Mathieu Almeida; Christian Brechot; Carlos Cara; Christian Chervaux; Antonella Cultrone; Christine Delorme; Gérard Denariaz; Rozenn Dervyn; Konrad U Foerstner; Carsten Friss; Maarten van de Guchte; Eric Guedon; Florence Haimet; Wolfgang Huber; Johan van Hylckama-Vlieg; Alexandre Jamet; Catherine Juste; Ghalia Kaci; Jan Knol; Omar Lakhdari; Severine Layec; Karine Le Roux; Emmanuelle Maguin; Alexandre Mérieux; Raquel Melo Minardi; Christine M'rini; Jean Muller; Raish Oozeer; Julian Parkhill; Pierre Renault; Maria Rescigno; Nicolas Sanchez; Shinichi Sunagawa; Antonio Torrejon; Keith Turner; Gaetana Vandemeulebrouck; Encarna Varela; Yohanan Winogradsky; Georg Zeller; Jean Weissenbach; S Dusko Ehrlich; Peer Bork
Journal:  Nature       Date:  2011-04-20       Impact factor: 49.962

2.  Serum N-glycan profile shift during human ageing.

Authors:  Valerie Vanhooren; Sylviane Dewaele; Claude Libert; Sebastiaan Engelborghs; Peter Paul De Deyn; Olivier Toussaint; Florence Debacq-Chainiaux; Michel Poulain; Youri Glupczynski; Claudio Franceschi; Koos Jaspers; Ingrid van der Pluijm; Jan Hoeijmakers; Cuiying Chitty Chen
Journal:  Exp Gerontol       Date:  2010-08-27       Impact factor: 4.032

3.  Gene expression profiling in Werner syndrome closely resembles that of normal aging.

Authors:  Kasper J Kyng; Alfred May; Steen Kølvraa; Vilhelm A Bohr
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-03       Impact factor: 11.205

4.  Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs.

Authors:  Rudolf P Talens; Kaare Christensen; Hein Putter; Gonneke Willemsen; Lene Christiansen; Dennis Kremer; H Eka D Suchiman; P Eline Slagboom; Dorret I Boomsma; Bastiaan T Heijmans
Journal:  Aging Cell       Date:  2012-06-04       Impact factor: 9.304

5.  A twin study of mitochondrial DNA polymorphisms shows that heteroplasmy at multiple sites is associated with mtDNA variant 16093 but not with zygosity.

Authors:  Toby Andrew; Cassandra D Calloway; Sarah Stuart; Sang Hoon Lee; Raj Gill; Gail Clement; Philip Chowienczyk; Tim D Spector; Ana M Valdes
Journal:  PLoS One       Date:  2011-08-03       Impact factor: 3.240

6.  Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.

Authors:  Jordana T Bell; Pei-Chien Tsai; Tsun-Po Yang; Ruth Pidsley; James Nisbet; Daniel Glass; Massimo Mangino; Guangju Zhai; Feng Zhang; Ana Valdes; So-Youn Shin; Emma L Dempster; Robin M Murray; Elin Grundberg; Asa K Hedman; Alexandra Nica; Kerrin S Small; Emmanouil T Dermitzakis; Mark I McCarthy; Jonathan Mill; Tim D Spector; Panos Deloukas
Journal:  PLoS Genet       Date:  2012-04-19       Impact factor: 5.917

7.  Transcriptional profiling of aging in human muscle reveals a common aging signature.

Authors:  Jacob M Zahn; Rebecca Sonu; Hannes Vogel; Emily Crane; Krystyna Mazan-Mamczarz; Ralph Rabkin; Ronald W Davis; Kevin G Becker; Art B Owen; Stuart K Kim
Journal:  PLoS Genet       Date:  2006-06-09       Impact factor: 5.917

8.  Widespread splicing changes in human brain development and aging.

Authors:  Pavel Mazin; Jieyi Xiong; Xiling Liu; Zheng Yan; Xiaoyu Zhang; Mingshuang Li; Liu He; Mehmet Somel; Yuan Yuan; Yi-Ping Phoebe Chen; Na Li; Yuhui Hu; Ning Fu; Zhibin Ning; Rong Zeng; Hongyi Yang; Wei Chen; Mikhail Gelfand; Philipp Khaitovich
Journal:  Mol Syst Biol       Date:  2013       Impact factor: 11.429

9.  An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways.

Authors:  James West; Stephan Beck; Xiangdong Wang; Andrew E Teschendorff
Journal:  Sci Rep       Date:  2013       Impact factor: 4.379

10.  Mapping cis- and trans-regulatory effects across multiple tissues in twins.

Authors:  Elin Grundberg; Kerrin S Small; Åsa K Hedman; Alexandra C Nica; Alfonso Buil; Sarah Keildson; Jordana T Bell; Tsun-Po Yang; Eshwar Meduri; Amy Barrett; James Nisbett; Magdalena Sekowska; Alicja Wilk; So-Youn Shin; Daniel Glass; Mary Travers; Josine L Min; Sue Ring; Karen Ho; Gudmar Thorleifsson; Augustine Kong; Unnur Thorsteindottir; Chrysanthi Ainali; Antigone S Dimas; Neelam Hassanali; Catherine Ingle; David Knowles; Maria Krestyaninova; Christopher E Lowe; Paola Di Meglio; Stephen B Montgomery; Leopold Parts; Simon Potter; Gabriela Surdulescu; Loukia Tsaprouni; Sophia Tsoka; Veronique Bataille; Richard Durbin; Frank O Nestle; Stephen O'Rahilly; Nicole Soranzo; Cecilia M Lindgren; Krina T Zondervan; Kourosh R Ahmadi; Eric E Schadt; Kari Stefansson; George Davey Smith; Mark I McCarthy; Panos Deloukas; Emmanouil T Dermitzakis; Tim D Spector
Journal:  Nat Genet       Date:  2012-09-02       Impact factor: 38.330
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  47 in total

1.  Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases.

Authors:  Jialiang Yang; Tao Huang; Francesca Petralia; Quan Long; Bin Zhang; Carmen Argmann; Yong Zhao; Charles V Mobbs; Eric E Schadt; Jun Zhu; Zhidong Tu
Journal:  Sci Rep       Date:  2015-10-19       Impact factor: 4.379

Review 2.  Advances in Biomarker Research in Parkinson's Disease.

Authors:  Shyamal H Mehta; Charles H Adler
Journal:  Curr Neurol Neurosci Rep       Date:  2016-01       Impact factor: 5.081

Review 3.  A synopsis on aging-Theories, mechanisms and future prospects.

Authors:  João Pinto da Costa; Rui Vitorino; Gustavo M Silva; Christine Vogel; Armando C Duarte; Teresa Rocha-Santos
Journal:  Ageing Res Rev       Date:  2016-06-25       Impact factor: 10.895

Review 4.  Human T cell immunosenescence and inflammation in aging.

Authors:  Arsun Bektas; Shepherd H Schurman; Ranjan Sen; Luigi Ferrucci
Journal:  J Leukoc Biol       Date:  2017-07-21       Impact factor: 4.962

Review 5.  The brain, sirtuins, and ageing.

Authors:  Akiko Satoh; Shin-Ichiro Imai; Leonard Guarente
Journal:  Nat Rev Neurosci       Date:  2017-05-18       Impact factor: 34.870

6.  Methods for Characterization of Senescent Circulating and Tumor-Infiltrating T-Cells: An Overview from Multicolor Flow Cytometry to Single-Cell RNA Sequencing.

Authors:  Rossana Franzin; Alessandra Stasi; Giuseppe Castellano; Loreto Gesualdo
Journal:  Methods Mol Biol       Date:  2021

Review 7.  Analysis of DNA modifications in aging research.

Authors:  Dustin R Masser; Niran Hadad; Hunter Porter; Michael B Stout; Archana Unnikrishnan; David R Stanford; Willard M Freeman
Journal:  Geroscience       Date:  2018-01-11       Impact factor: 7.713

Review 8.  Blue journal conference. Aging and susceptibility to lung disease.

Authors:  Victor J Thannickal; Mahadev Murthy; William E Balch; Navdeep S Chandel; Silke Meiners; Oliver Eickelberg; Moisés Selman; Annie Pardo; Eric S White; Bruce D Levy; Paula J Busse; Rubin M Tuder; Veena B Antony; Jacob I Sznajder; G R Scott Budinger
Journal:  Am J Respir Crit Care Med       Date:  2015-02-01       Impact factor: 21.405

Review 9.  The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease.

Authors:  Herbert B Schiller; Daniel T Montoro; Lukas M Simon; Emma L Rawlins; Kerstin B Meyer; Maximilian Strunz; Felipe A Vieira Braga; Wim Timens; Gerard H Koppelman; G R Scott Budinger; Janette K Burgess; Avinash Waghray; Maarten van den Berge; Fabian J Theis; Aviv Regev; Naftali Kaminski; Jayaraj Rajagopal; Sarah A Teichmann; Alexander V Misharin; Martijn C Nawijn
Journal:  Am J Respir Cell Mol Biol       Date:  2019-07       Impact factor: 6.914

Review 10.  Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease in focal cerebral ischemic rats.

Authors:  Mak Adam Daulatzai
Journal:  Am J Neurodegener Dis       Date:  2016-06-01
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