BACKGROUND: There has been increasing interest in the entity of Non-Celiac Gluten Sensitivity (NCGS) in recent years; however, it still remains a controversial topic and its pathogenesis is not well understood. Celiac Disease, in contrast, is a well-studied condition that has become increasingly recognized as a prevalent condition arising from a heightened immunological response to gluten. Wheat allergy is an IgE-mediated condition capable of causing a variety of gastrointestinal symptoms. However, the number of patients who have neither celiac disease nor wheat allergy, but appear to derive benefit from a gluten-free diet, is also increasing substantially. The use of the term NCGS as a way of describing this condition has become increasingly prevalent in recent years. PURPOSE: In this review, we will focus on gastrointestinal manifestations of NCGS and discuss the evidence for the condition and its putative pathogenesis. We will discuss areas of controversy and areas for potential future research.
BACKGROUND: There has been increasing interest in the entity of Non-Celiac Gluten Sensitivity (NCGS) in recent years; however, it still remains a controversial topic and its pathogenesis is not well understood. Celiac Disease, in contrast, is a well-studied condition that has become increasingly recognized as a prevalent condition arising from a heightened immunological response to gluten. Wheatallergy is an IgE-mediated condition capable of causing a variety of gastrointestinal symptoms. However, the number of patients who have neither celiac disease nor wheatallergy, but appear to derive benefit from a gluten-free diet, is also increasing substantially. The use of the term NCGS as a way of describing this condition has become increasingly prevalent in recent years. PURPOSE: In this review, we will focus on gastrointestinal manifestations of NCGS and discuss the evidence for the condition and its putative pathogenesis. We will discuss areas of controversy and areas for potential future research.
Authors: Rok Seon Choung; Ivo C Ditah; Ashley M Nadeau; Alberto Rubio-Tapia; Eric V Marietta; Tricia L Brantner; Michael J Camilleri; S Vincent Rajkumar; Ola Landgren; James E Everhart; Joseph A Murray Journal: Am J Gastroenterol Date: 2015-02-10 Impact factor: 10.864
Authors: Diana Di Liberto; Pasquale Mansueto; Alberto D'Alcamo; Marianna Lo Pizzo; Elena Lo Presti; Girolamo Geraci; Francesca Fayer; Giuliana Guggino; Giuseppe Iacono; Francesco Dieli; Antonio Carroccio Journal: Clin Transl Gastroenterol Date: 2016-07-07 Impact factor: 4.488
Authors: Fernando Fernández-Bañares; Beatriz Arau; Agnès Raga; Montserrat Aceituno; Eva Tristán; Anna Carrasco; Laura Ruiz; Albert Martín-Cardona; Pablo Ruiz-Ramírez; Maria Esteve Journal: Nutrients Date: 2021-05-26 Impact factor: 5.717