AIMS: A better understanding of treatment patterns and outcomes in different countries should improve the management of patients with gastric cancer globally. The REgistry of GAstric Cancer Treatment Evaluation (REGATE) study was established to evaluate variations in gastric cancer disease characteristics and treatment patterns in different parts of the world. METHODS: REGATE was a prospective international registry enrolling patients with newly diagnosed gastric cancer at any stage of the disease. RESULTS: A total of 10 299 patients (65% male; mean age 59 years) were recruited in 22 countries between 2004 and 2008. Tumor location at a proximal site was more common in Europe, Latin America and North Africa (approximately 20%) than in Asia-Pacific, where antral location predominated. Signet-ring cell histology predominated except in Europe, where adenocarcinoma was most prevalent. Stage I cancers were more frequent in Asia-Pacific (39%) versus other regions (6-18%), whereas stage IV cancers were more frequent outside Asia-Pacific. Surgery was planned for most patients, although in general fewer patients actually received surgery than originally planned. Adjuvant therapy and palliative care were generally used more frequently than originally planned. Overall, 15% of patients received no treatment (Asia-Pacific 8%; Indian subcontinent 25%). CONCLUSIONS: These results provide a comprehensive database representative of gastric cancer disease characteristics and treatment patterns across the world.
AIMS: A better understanding of treatment patterns and outcomes in different countries should improve the management of patients with gastric cancer globally. The REgistry of GAstric Cancer Treatment Evaluation (REGATE) study was established to evaluate variations in gastric cancer disease characteristics and treatment patterns in different parts of the world. METHODS: REGATE was a prospective international registry enrolling patients with newly diagnosed gastric cancer at any stage of the disease. RESULTS: A total of 10 299 patients (65% male; mean age 59 years) were recruited in 22 countries between 2004 and 2008. Tumor location at a proximal site was more common in Europe, Latin America and North Africa (approximately 20%) than in Asia-Pacific, where antral location predominated. Signet-ring cell histology predominated except in Europe, where adenocarcinoma was most prevalent. Stage I cancers were more frequent in Asia-Pacific (39%) versus other regions (6-18%), whereas stage IV cancers were more frequent outside Asia-Pacific. Surgery was planned for most patients, although in general fewer patients actually received surgery than originally planned. Adjuvant therapy and palliative care were generally used more frequently than originally planned. Overall, 15% of patients received no treatment (Asia-Pacific 8%; Indian subcontinent 25%). CONCLUSIONS: These results provide a comprehensive database representative of gastric cancer disease characteristics and treatment patterns across the world.
Authors: Jin Won Kim; Jong Gwang Kim; Byung Woog Kang; Ik-Joo Chung; Young Seon Hong; Tae-You Kim; Hong Suk Song; Kyung Hee Lee; Dae Young Zang; Yoon Ho Ko; Eun-Kee Song; Jin Ho Baek; Dong-Hoe Koo; So Yeon Oh; Hana Cho; Keun-Wook Lee Journal: Cancer Res Treat Date: 2018-10-19 Impact factor: 4.679
Authors: Bilal Alkhaffaf; Aleksandra Metryka; Jane M Blazeby; Anne-Marie Glenny; Paula R Williamson; Iain A Bruce Journal: PLoS One Date: 2021-12-31 Impact factor: 3.240
Authors: Gebra Cuyun Carter; Anna Kaltenboeck; Jasmina Ivanova; Astra M Liepa; Alexandra San Roman; Maria Koh; Narayan Rajan; Rebecca Cheng; Howard G Birnbaum; Jong Seok Kim; Yung-Jue Bang Journal: Cancer Res Treat Date: 2016-09-12 Impact factor: 4.679
Authors: Ian Chau; Dung T Le; Patrick A Ott; Beata Korytowsky; Hannah Le; T Kim Le; Ying Zhang; Teresa Sanchez; Gregory A Maglinte; Melissa Laurie; Pranav Abraham; Dhiren Patel; Tong Shangguan Journal: Gastric Cancer Date: 2019-09-23 Impact factor: 7.370