Literature DB >> 23935200

Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in Ghanaian children.

Bright Adu1, Micha Phill Grønholm Jepsen, Thomas A Gerds, Eric Kyei-Baafour, Michael Christiansen, Daniel Dodoo, Michael Theisen.   

Abstract

Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.

Entities:  

Keywords:  FCGR3B-c.233C>A; FcγRIIIB; GLURP; Plasmodium falciparum; effect modification; malaria; neutrophils

Mesh：

Substances：

Year:  2013        PMID： 23935200     DOI： 10.1093/infdis/jit422

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

1.  Molecular and Functional Characterization of Fcγ Receptor IIIb-Ligand Interaction: Implications for Neutrophil-Mediated Immune Mechanisms in Malaria.

Authors:  Ulrich J Sachs; Sentot Santoso; Piyapong Simtong; Amornrat V Romphruk; Annalena Traum; Monika Burg-Roderfeld; Gregor Bein; Konstantin Jakubowski; Andreas Dominik; Michael Theisen; Ikhlaq Hussain Kana
Journal:  Infect Immun       Date:  2018-07-23       Impact factor: 3.441

2.  Identification of Fc Gamma Receptor Glycoforms That Produce Differential Binding Kinetics for Rituximab.

Authors:  Jerrard M Hayes; Asa Frostell; Robert Karlsson; Steffen Müller; Silvia Míllan Martín; Martin Pauers; Franziska Reuss; Eoin F Cosgrave; Cecilia Anneren; Gavin P Davey; Pauline M Rudd
Journal:  Mol Cell Proteomics       Date:  2017-06-02       Impact factor: 5.911

3.  Genome-wide association study of antibody responses to Plasmodium falciparum candidate vaccine antigens.

Authors:  J Milet; A Sabbagh; F Migot-Nabias; A J F Luty; O Gaye; A Garcia; D Courtin
Journal:  Genes Immun       Date:  2016-01-07       Impact factor: 2.676

4.  Peripheral Merozoite Surface Proteins Are Targets of Naturally Acquired Immunity against Malaria in both India and Ghana.

Authors:  Asier Garcia-Senosiain; Ikhlaq Hussain Kana; Susheel Kumar Singh; Bishwanath Kumar Chourasia; Manoj Kumar Das; Daniel Dodoo; Subhash Singh; Bright Adu; Michael Theisen
Journal:  Infect Immun       Date:  2020-03-23       Impact factor: 3.441

Review 5.  The role of Fc receptors in HIV prevention and therapy.

Authors:  Austin W Boesch; Eric P Brown; Margaret E Ackerman
Journal:  Immunol Rev       Date:  2015-11       Impact factor: 12.988

6.  High-throughput tri-colour flow cytometry technique to assess Plasmodium falciparum parasitaemia in bioassays.

Authors:  Regis W Tiendrebeogo; Bright Adu; Susheel K Singh; Daniel Dodoo; Morten H Dziegiel; Benjamin Mordmüller; Issa Nébié; Sodiomon B Sirima; Michael Christiansen; Michael Theisen
Journal:  Malar J       Date:  2014-10-20       Impact factor: 2.979

7.  Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood-Stage Proteins of Plasmodium vivax.

Authors:  Gustavo C Cassiano; Adriana A C Furini; Marcela P Capobianco; Luciane M Storti-Melo; Maristela G Cunha; Flora S Kano; Luzia H Carvalho; Irene S Soares; Sidney E Santos; Marinete M Póvoa; Ricardo L D Machado
Journal:  PLoS One       Date:  2016-02-22       Impact factor: 3.240

8.  Antibody levels against GLURP R2, MSP1 block 2 hybrid and AS202.11 and the risk of malaria in children living in hyperendemic (Burkina Faso) and hypo-endemic (Ghana) areas.

Authors:  Bright Adu; Mariama K Cherif; Samuel Bosomprah; Amidou Diarra; Fareed K N Arthur; Emmanuel K Dickson; Giampietro Corradin; David R Cavanagh; Michael Theisen; Sodiomon B Sirima; Issa Nebie; Daniel Dodoo
Journal:  Malar J       Date:  2016-02-27       Impact factor: 2.979

9.  Antibody-Dependent Cellular Inhibition Is Associated With Reduced Risk Against Febrile Malaria in a Longitudinal Cohort Study Involving Ghanaian Children.

Authors:  Regis W Tiendrebeogo; Bright Adu; Susheel K Singh; Morten H Dziegiel; Issa Nébié; Sodiomon B Sirima; Michael Christiansen; Daniel Dodoo; Michael Theisen
Journal:  Open Forum Infect Dis       Date:  2015-04-10       Impact factor: 3.835

Review 10.  Recent advances in recombinant protein-based malaria vaccines.

Authors:  Simon J Draper; Evelina Angov; Toshihiro Horii; Louis H Miller; Prakash Srinivasan; Michael Theisen; Sumi Biswas
Journal:  Vaccine       Date:  2015-10-11       Impact factor: 3.641
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