Literature DB >> 2393403

Counter-regulatory effects of phosphatidic acid on protein kinase C activity in the presence of calcium and diolein.

R M Epand1, A R Stafford.   

Abstract

Phosphatidic acid can replace phosphatidylserine in the activation of protein kinase C. However, in the presence of diolein, the addition of Ca2+ results in the inhibition of the enzyme. This phenomenon could lead to a negative feedback regulation of protein kinase C activity as a result of stimulation of the cycling of phosphatidylinositol.

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Year:  1990        PMID: 2393403     DOI: 10.1016/0006-291x(90)91419-s

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN: 0006-291X            Impact factor:   3.575


  2 in total

1.  Rapid desensitization and resensitization of bombesin-stimulated phospholipase D activity in Swiss 3T3 cells.

Authors:  C P Briscoe; R Plevin; M J Wakelam
Journal:  Biochem J       Date:  1994-02-15       Impact factor: 3.857

2.  Purification and characterization of N-ethylmaleimide-insensitive phosphatidic acid phosphohydrolase (PAP2) from rat liver.

Authors:  I N Fleming; S J Yeaman
Journal:  Biochem J       Date:  1995-06-15       Impact factor: 3.857

  2 in total

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