PURPOSE: To investigate the association of Progesterone Receptor (PR) gene variations and male infertility METHODS: DNA extraction, PCR and sequencing of PR gene, PROGINS insertion by PCR. Association of the variations with seminal parameters and outcomes of ICSI. RESULTS: Four known SNPs in the PR gene were identified in the study of which three (rs3740753, rs1042838, rs104283) were co-inherited and in complete linkage disequilibrium with the PROGINS Alu insertion. There were no differences in their frequencies between fertile and infertile males. The rs2020880 was found at a very low frequency only in the controls but not in the infertile subjects. The sperm counts, fertilization rate, embryo quality or pregnancy rates were not different in individuals with or without PROGINS allele. CONCLUSION: PR gene alterations are not associated with male infertility or ICSI outcome.
PURPOSE: To investigate the association of Progesterone Receptor (PR) gene variations and male infertility METHODS: DNA extraction, PCR and sequencing of PR gene, PROGINS insertion by PCR. Association of the variations with seminal parameters and outcomes of ICSI. RESULTS: Four known SNPs in the PR gene were identified in the study of which three (rs3740753, rs1042838, rs104283) were co-inherited and in complete linkage disequilibrium with the PROGINS Alu insertion. There were no differences in their frequencies between fertile and infertile males. The rs2020880 was found at a very low frequency only in the controls but not in the infertile subjects. The sperm counts, fertilization rate, embryo quality or pregnancy rates were not different in individuals with or without PROGINS allele. CONCLUSION:PR gene alterations are not associated with male infertility or ICSI outcome.
Authors: Robert I McLachlan; Liza O'Donnell; Peter G Stanton; Georgia Balourdos; Mark Frydenberg; David M de Kretser; David M Robertson Journal: J Clin Endocrinol Metab Date: 2002-02 Impact factor: 5.958
Authors: R A Bebb; B D Anawalt; R B Christensen; C A Paulsen; W J Bremner; A M Matsumoto Journal: J Clin Endocrinol Metab Date: 1996-02 Impact factor: 5.958
Authors: Andreas Schweikert; Thomas Rau; Alexander Berkholz; Axel Allera; Sabine Daufeldt; Ludwig Wildt Journal: Eur J Obstet Gynecol Reprod Biol Date: 2004-03-15 Impact factor: 2.435