Alessandro De Stefano1, Francesco Dispenza2, Hamlet Suarez3, Nicolas Perez-Fernandez4, Raquel Manrique-Huarte4, Jae Ho Ban5, Min-Beom Kim, Min Beom Kim5, Michael Strupp6, Katharina Feil6, Carlos A Oliveira7, Andres L Sampaio7, Mercedes F S Araujo7, Fayez Bahmad7, Mauricio M Ganança8, Fernando F Ganança8, Ricardo Dorigueto8, Hyung Lee9, Gautham Kulamarva10, Navneet Mathur11, Pamela Di Giovanni12, Anna Grazia Petrucci13, Tommaso Staniscia14, Leonardo Citraro15, Adelchi Croce15. 1. ENT Institute, Department of Oral and Nano-Biotechnological Sciences, "G. d'Annunzio" University of Chieti-Pescara, Italy. Electronic address: dr.adestefano@gmail.com. 2. Department of Otorhinolaryngology, "San Giovanni di Dio" Hospital of Agrigento, University of Palermo, Italy. 3. Laboratory of Otoneurology, British Hospital of Montevideo, "CLAEH" School of Medicine, Montevideo, Uruguay. 4. Department of Otorhinolaryngology, Clinica Universidad de Navarra, University of Navarra, Pamplona, Spain. 5. Department of Otolaryngology, SKKU University of Seoul, South Korea. 6. Department of Neurology "Ludwig-Maximilians", University of Munich, Germany. 7. Department of Otorhinolaryngology, University of Brasilia, Brazil. 8. Department of Otolaryngology, Federal University of Saõ Paulo, Brazil. 9. Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea. 10. Department of Otolaryngology, KIMS Hospital of Kasaragod, India. 11. RNT Medical College of Udaipur, India. 12. Department of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, Italy. 13. Postgraduate School of Public Health and Preventive Medicine, "G. d'Annunzio" University of Chieti-Pescara, Italy. 14. Department of Medicine and Aging, "G. d'Annunzio" University of Chieti-Pescara, Italy. 15. ENT Institute, Department of Oral and Nano-Biotechnological Sciences, "G. d'Annunzio" University of Chieti-Pescara, Italy.
Abstract
OBJECTIVE: Primary objective of this study was to find a statistical link between the most worldwide comorbidities affecting the elderly population (hypertension, diabetes, osteoarthrosis, osteoporosis and depression) and recurrent episodes of BPPV. Secondary objective was defining possible "groups of risk" for people suffering recurrent positional vertigo related to the presence of a well documented comorbidity. METHODS: This was an observational, cross-sectional, multicenter, spontaneous, non-pharmacological study. The data of 1092 patients suffering BPPV evaluated in 11 different Departments of Otolaryngology, Otoneurology and Neurology, referring Centers for positional vertigo evaluation, were retrospectively collected. RESULTS: Regarding evaluated comorbidities (hypertension, diabetes, osteoarthrosis, osteoporosis and depression), data analysis showed the presence of at least one comorbid disorder in 216 subjects (19.8%) and 2 or more in 408 subjects (37.4%). Moreover there was a statistical significant difference between the number of comorbidities and the number of recurrences, otherwise said as comorbidity disorders increased the number of relapses increased too. CONCLUSION: The presence of a systemic disease may worsen the status of the posterior labyrinth causing a more frequent otolith detachment. This condition increases the risk for patients suffering BPPV to have recurrent episodes, even if correctly managed by repositioning maneuvers. The combination of two or more of aforementioned comorbidities further increases the risk of relapsing BPPV, worsened by the presence of osteoporosis. On the basis of this results it was possible to define "groups of risk" useful for predicting BPPV recurrence in patients with one or more comorbidity.
OBJECTIVE: Primary objective of this study was to find a statistical link between the most worldwide comorbidities affecting the elderly population (hypertension, diabetes, osteoarthrosis, osteoporosis and depression) and recurrent episodes of BPPV. Secondary objective was defining possible "groups of risk" for people suffering recurrent positional vertigo related to the presence of a well documented comorbidity. METHODS: This was an observational, cross-sectional, multicenter, spontaneous, non-pharmacological study. The data of 1092 patients suffering BPPV evaluated in 11 different Departments of Otolaryngology, Otoneurology and Neurology, referring Centers for positional vertigo evaluation, were retrospectively collected. RESULTS: Regarding evaluated comorbidities (hypertension, diabetes, osteoarthrosis, osteoporosis and depression), data analysis showed the presence of at least one comorbid disorder in 216 subjects (19.8%) and 2 or more in 408 subjects (37.4%). Moreover there was a statistical significant difference between the number of comorbidities and the number of recurrences, otherwise said as comorbidity disorders increased the number of relapses increased too. CONCLUSION: The presence of a systemic disease may worsen the status of the posterior labyrinth causing a more frequent otolith detachment. This condition increases the risk for patients suffering BPPV to have recurrent episodes, even if correctly managed by repositioning maneuvers. The combination of two or more of aforementioned comorbidities further increases the risk of relapsing BPPV, worsened by the presence of osteoporosis. On the basis of this results it was possible to define "groups of risk" useful for predicting BPPV recurrence in patients with one or more comorbidity.
Authors: Linda J D'Silva; Hinrich Staecker; James Lin; Kevin J Sykes; Milind A Phadnis; Tamara M McMahon; Dan Connolly; Carla H Sabus; Susan L Whitney; Patricia M Kluding Journal: J Vestib Res Date: 2016 Impact factor: 2.435
Authors: Linda J D'Silva; Patricia M Kluding; Susan L Whitney; Hongying Dai; Marcio Santos Journal: Int J Neurosci Date: 2017-04-25 Impact factor: 2.292
Authors: Marta Alvarez de Linera-Alperi; Octavio Garaycochea; Diego Calavia; David Terrasa; Nicolas Pérez-Fernández; Raquel Manrique-Huarte Journal: Audiol Res Date: 2022-06-19
Authors: F Dispenza; A DE Stefano; C Costantino; D Rando; M Giglione; R Stagno; E Bennici Journal: Acta Otorhinolaryngol Ital Date: 2015-04 Impact factor: 2.124