Literature DB >> 23932019

Telomerase: central regulator of all of the hallmarks of cancer.

Kee Chung Low1, Vinay Tergaonkar.   

Abstract

The hallmarks of cancer described by Hanahan and Weinberg are properties that cancer cells must possess for successful transformation. It is believed that each of these hallmarks is independently driven. Although elongation of telomeres is thought to be the prime function of reactivated telomerase reverse transcriptase, this activity does not account for all its effects, such as increasing cell proliferation, resistance to apoptosis, and invasion. Recent studies suggest that the telomerase subunit telomerase reverse transcriptase (TERT) has novel molecular functions including transcriptional regulation and metabolic reprogramming. We summarize these functions and discuss how they could directly regulate the various hallmarks of cancer. Finally, we suggest that therapeutics targeting noncanonical telomerase functions may work better than those that target its role in telomere extension. 2013 Elsevier Ltd. All rights reserved

Entities:  

Keywords:  apoptosis; cancer; hTERT; signaling; telomere

Mesh：

Substances：

Year:  2013        PMID： 23932019     DOI： 10.1016/j.tibs.2013.07.001

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  96 in total

1.  hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness.

Authors:  M J Choi; K H Cho; S Lee; Y J Bae; K J Jeong; S Y Rha; E J Choi; J H Park; J M Kim; J-S Lee; G B Mills; H Y Lee
Journal:  Oncogene       Date:  2014-08-25       Impact factor: 9.867

2.  Investigation of Leukocyte Telomere Length and Genetic Variants in Chromosome 5p15.33 as Prognostic Markers in Lung Cancer.

Authors:  Linda Kachuri; Jens Helby; Stig Egil Bojesen; David C Christiani; Li Su; Xifeng Wu; Adonina Tardón; Guillermo Fernández-Tardón; John K Field; Michael P Davies; Chu Chen; Gary E Goodman; Frances A Shepherd; Natasha B Leighl; Ming S Tsao; Yonathan Brhane; M Catherine Brown; Kevin Boyd; Daniel Shepshelovich; Lei Sun; Christopher I Amos; Geoffrey Liu; Rayjean J Hung
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2019-07       Impact factor: 4.254

Review 3.  Causes of genome instability: the effect of low dose chemical exposures in modern society.

Authors:  Sabine A S Langie; Gudrun Koppen; Daniel Desaulniers; Fahd Al-Mulla; Rabeah Al-Temaimi; Amedeo Amedei; Amaya Azqueta; William H Bisson; Dustin G Brown; Gunnar Brunborg; Amelia K Charles; Tao Chen; Annamaria Colacci; Firouz Darroudi; Stefano Forte; Laetitia Gonzalez; Roslida A Hamid; Lisbeth E Knudsen; Luc Leyns; Adela Lopez de Cerain Salsamendi; Lorenzo Memeo; Chiara Mondello; Carmel Mothersill; Ann-Karin Olsen; Sofia Pavanello; Jayadev Raju; Emilio Rojas; Rabindra Roy; Elizabeth P Ryan; Patricia Ostrosky-Wegman; Hosni K Salem; A Ivana Scovassi; Neetu Singh; Monica Vaccari; Frederik J Van Schooten; Mahara Valverde; Jordan Woodrick; Luoping Zhang; Nik van Larebeke; Micheline Kirsch-Volders; Andrew R Collins
Journal:  Carcinogenesis       Date:  2015-06       Impact factor: 4.944

4.  Metastases free thyroid cancer patients harbouring TERT mutations may benefit from a more intensive treatment and follow-up.

Authors:  Alessandro Antonelli; Silvia Martina Ferrari; Giusy Elia; Armando Patrizio; Poupak Fallahi
Journal:  Gland Surg       Date:  2019-06

Review 5.  A second chance for telomerase reverse transcriptase in anticancer immunotherapy.

Authors:  Maurizio Zanetti
Journal:  Nat Rev Clin Oncol       Date:  2016-06-01       Impact factor: 66.675

Review 6.  Genetic-guided Risk Assessment and Management of Thyroid Cancer.

Authors:  Mingzhao Xing
Journal:  Endocrinol Metab Clin North Am       Date:  2019-03       Impact factor: 4.741

Review 7.  Transcriptional outcome of telomere signalling.

Authors:  Jing Ye; Valérie M Renault; Karine Jamet; Eric Gilson
Journal:  Nat Rev Genet       Date:  2014-06-10       Impact factor: 53.242

Review 8.  "Ins" and "Outs" of mesenchymal stem cell osteogenesis in regenerative medicine.

Authors:  Dean T Yamaguchi
Journal:  World J Stem Cells       Date:  2014-04-26       Impact factor: 5.326

9.  Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.

Authors:  Yinghui Li; Qi-Ling Zhou; Wenjie Sun; Prashant Chandrasekharan; Hui Shan Cheng; Zhe Ying; Manikandan Lakshmanan; Anandhkumar Raju; Daniel G Tenen; Shi-Yuan Cheng; Kai-Hsiang Chuang; Jun Li; Shyam Prabhakar; Mengfeng Li; Vinay Tergaonkar
Journal:  Nat Cell Biol       Date:  2015-09-21       Impact factor: 28.824

10.  Whole-exome sequencing characterizes the landscape of somatic mutations and copy number alterations in adrenocortical carcinoma.

Authors:  C Christofer Juhlin; Gerald Goh; James M Healy; Annabelle L Fonseca; Ute I Scholl; Adam Stenman; John W Kunstman; Taylor C Brown; John D Overton; Shrikant M Mane; Carol Nelson-Williams; Martin Bäckdahl; Anna-Carinna Suttorp; Matthias Haase; Murim Choi; Joseph Schlessinger; David L Rimm; Anders Höög; Manju L Prasad; Reju Korah; Catharina Larsson; Richard P Lifton; Tobias Carling
Journal:  J Clin Endocrinol Metab       Date:  2014-12-09       Impact factor: 5.958
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