| Literature DB >> 23929461 |
Zaquer Suzana Munhoz Costa-Ferro1, Fernanda de Borba Cunha, Bruno Solano de Freitas Souza, Marcos Maurício Tosta Leal, Adelson Alves da Silva, Telma Ingrid Borges de Bellis Kühn, Andresa Forte, Eliseo Joji Sekiya, Milena Botelho Pereira Soares, Ricardo Ribeiro Dos Santos.
Abstract
Status epilepticus (SE) is a condition of persistent seizure that leads to brain damage and, frequently, to the establishment of chronic epilepsy. Cord blood is an important source of adult stem cells for the treatment of neurological disorders. The present study aimed to evaluate the effects of human umbilical cord blood mononuclear cells (HUCBC) transplanted into rats after induction of SE by the administration of lithium and pilocarpine chloride. Transplantation of HUCBC into epileptic rats protected against neuronal loss in the hippocampal subfields CA1, CA3 and in the hilus of the dentate gyrus, up to 300 days after SE induction. Moreover, transplanted rats had reduced frequency and duration of spontaneous recurrent seizures (SRS) 15, 120 and 300 days after the SE. Our study shows that HUCBC provide prominent antiepileptic and neuroprotective effects in the experimental model of epilepsy and reinforces that early interventions can protect the brain against the establishment of epilepsy.Entities:
Year: 2013 PMID： 23929461 PMCID： PMC3918271 DOI： 10.1007/s10616-013-9557-3
Source DB: PubMed Journal: Cytotechnology ISSN： 0920-9069 Impact factor: 2.058