CONTEXT: Growing evidence demonstrates that hyperparathyroidism is associated with an increased risk of cardiovascular morbidity and mortality. However, little is known about the relation between serum PTH levels within the normal range and cardiovascular diseases (CVD). OBJECTIVE: In this study the relationship of serum PTH levels within the normal range with CVD and abdominal aortic calcifications was investigated. DESIGN: A cross-sectional, population-based study was performed using data of the Longitudinal Aging Study Amsterdam, including 558 men and 537 women, aged 65-88 years. Models were controlled for sex, age, body mass index, hypertension, diabetes mellitus, high-density lipoprotein cholesterol, total cholesterol, smoking, physical activity, alcohol consumption, glomerular filtration rate, season of blood collection, calcium or diuretic use, and serum 25-hydroxyvitamin D and osteocalcin levels when these variables were found to be relevant confounders. RESULTS: Multivariate models showed that subjects in the highest quintile of serum PTH had a significantly higher risk of CVD as compared with subjects in the lowest quintile (odds ratio 2.22, confidence interval 1.39-3.56). The relationship between PTH and abdominal aortic calcifications was observed only in men, which remained significant after adjusting for confounders (odds ratio 4.03, confidence interval 1.50-10.83). CONCLUSIONS: This study demonstrated that in older persons the presence of serum PTH levels within the upper normal range is highly related to CVD. In men, this association may partly be explained by calcifications of the abdominal aorta. Because CVD poses an important health risk, further elucidation of the role of serum PTH in CVD and arteriosclerosis is relevant.
CONTEXT: Growing evidence demonstrates that hyperparathyroidism is associated with an increased risk of cardiovascular morbidity and mortality. However, little is known about the relation between serum PTH levels within the normal range and cardiovascular diseases (CVD). OBJECTIVE: In this study the relationship of serum PTH levels within the normal range with CVD and abdominal aortic calcifications was investigated. DESIGN: A cross-sectional, population-based study was performed using data of the Longitudinal Aging Study Amsterdam, including 558 men and 537 women, aged 65-88 years. Models were controlled for sex, age, body mass index, hypertension, diabetes mellitus, high-density lipoprotein cholesterol, total cholesterol, smoking, physical activity, alcohol consumption, glomerular filtration rate, season of blood collection, calcium or diuretic use, and serum 25-hydroxyvitamin D and osteocalcin levels when these variables were found to be relevant confounders. RESULTS: Multivariate models showed that subjects in the highest quintile of serum PTH had a significantly higher risk of CVD as compared with subjects in the lowest quintile (odds ratio 2.22, confidence interval 1.39-3.56). The relationship between PTH and abdominal aortic calcifications was observed only in men, which remained significant after adjusting for confounders (odds ratio 4.03, confidence interval 1.50-10.83). CONCLUSIONS: This study demonstrated that in older persons the presence of serum PTH levels within the upper normal range is highly related to CVD. In men, this association may partly be explained by calcifications of the abdominal aorta. Because CVD poses an important health risk, further elucidation of the role of serum PTH in CVD and arteriosclerosis is relevant.
Authors: A Concistrè; A Grillo; G La Torre; R Carretta; B Fabris; L Petramala; C Marinelli; A Rebellato; F Fallo; C Letizia Journal: Endocrine Date: 2017-07-12 Impact factor: 3.633
Authors: M Procopio; M Barale; S Bertaina; S Sigrist; R Mazzetti; M Loiacono; G Mengozzi; E Ghigo; M Maccario Journal: Endocrine Date: 2013-11-28 Impact factor: 3.633
Authors: Xi Zhang; Wanzhu Tu; JoAnn E Manson; Lesley Tinker; Simin Liu; Jane A Cauley; Lihong Qi; Charles Mouton; Lisa W Martin; Lifang Hou; Yiqing Song Journal: J Am Heart Assoc Date: 2019-02-19 Impact factor: 5.501
Authors: Emiel O Hoogendijk; Dorly J H Deeg; Jan Poppelaars; Marleen van der Horst; Marjolein I Broese van Groenou; Hannie C Comijs; H Roeline W Pasman; Natasja M van Schoor; Bianca Suanet; Fleur Thomése; Theo G van Tilburg; Marjolein Visser; Martijn Huisman Journal: Eur J Epidemiol Date: 2016-08-20 Impact factor: 8.082