| Literature DB >> 23928507 |
Eugenia Gallo1, Valentina Maggini, Margherita Berardi, Alessandra Pugi, Rosario Notaro, Giulia Talini, Giancarlo Vannozzi, Siro Bagnoli, Paolo Forte, Alessandro Mugelli, Vito Annese, Fabio Firenzuoli, Alfredo Vannacci.
Abstract
A case of autoimmune liver hepatitis is reported: the onset was triggered by consumption of green tea infusion in a patient taking oral contraceptives and irbesartan. We hypothesize that our patient, carrying genetic variant of hepatic metabolism making her particularly susceptible to oxidative stress, developed an abnormal response to a mild toxic insult, afforded by a combination of agents (oral contraceptives+irbesartan+green tea) that normally would not be able to cause damage. Her particular hepatic metabolism further increased the drugs' concentration, favoring the haptenization of liver proteins, eventually leading to the development of an autoimmune hepatitis.Entities:
Keywords: AIH; ALT; AP; Autoimmune hepatitis; CYP; Catechin; EGCG; GGT; GST; Green tea; MDR; MTHFR; SULT; Single nucleotide polymorphism; UDP glucuronosyltransferase; UGT; alanine aminotransferase; alkaline phosphatase; autoimmune like hepatitis; cytochrome P450; epigallocatechin-3-gallate; glutamiltransferase; glutathione S-transferase; methylenetetrahydrofolate reductase; multidrug resistance; sulfotransferase
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Year: 2013 PMID: 23928507 DOI: 10.1016/j.phymed.2013.07.004
Source DB: PubMed Journal: Phytomedicine ISSN: 0944-7113 Impact factor: 5.340